Apoptosis of T lymphocytes in acute disseminated encephalomyelitis

被引：20
作者：
Bauer, J
Stadelmann, C
Bancher, C
Jellinger, K
Lassmann, H
机构：
[1] Univ Vienna, Inst Neurol, A-1090 Vienna, Austria
[2] Hosp Lainz, Dept Neurol, Vienna, Austria
[3] Lainz Hosp, Ludwig Boltzmann Inst Clin Neurobiol, A-1130 Vienna, Austria
来源：
ACTA NEUROPATHOLOGICA | 1999年 / 97卷 / 06期
基金：
奥地利科学基金会;
关键词：
D O I：
10.1007/s004010051028
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Apoptosis has been shown to be an efficient mechanism involved in clearance of T lymphocytes from the brains of animals with acute experimental autoimmune encephalomyelitis (EAE), an animal model for human multiple sclerosis. in this report we describe a case of acute disseminated encephalomyelitis following general measles infection. In this disease, which closely mimics the pathology of acute EAE we found a high percentage (30%) of apoptotic T cells. This indicates that in both rodent and human brain clearance of T cell-mediated inflammation follows similar mechanisms.
引用
收藏
页码：543 / 546
页数：4
相关论文
共 18 条
[1]  
ADAMS JM, 1966, JAMA-J AM MED ASSOC, V196, P150
[2]  
ALVORD EC, 1970, HDB CLINICAL NEUROLO, V9, P500
[3]   T-cell apoptosis in inflammatory brain lesions - Destruction of T cells does not depend on antigen recognition [J].
Bauer, J ;
Bradl, M ;
Hickey, WF ;
Forss-Petter, S ;
Breitschopf, H ;
Linington, C ;
Wekerle, H ;
Lassmann, H .
AMERICAN JOURNAL OF PATHOLOGY, 1998, 153 (03) :715-724
[4]  
BREITSCHOPF H, 1992, ACTA NEUROPATHOL, V84, P581
[5]   Cell death and birth in multiple sclerosis brain [J].
Dowling, P ;
Husar, W ;
Menonna, J ;
Donnenfeld, H ;
Cook, S ;
Sidhu, M .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1997, 149 (01) :1-11
[6]   T-cell apoptosis in autoimmune diseases: termination of inflammation in the nervous system and other sites with specialized immune-defense mechanisms [J].
Gold, R ;
Hartung, HP ;
Lassmann, H .
TRENDS IN NEUROSCIENCES, 1997, 20 (09) :399-404
[7]  
GOLD R, 1994, LAB INVEST, V71, P219
[8]   MEASLES ENCEPHALOMYELITIS - CLINICAL AND IMMUNOLOGICAL STUDIES [J].
JOHNSON, RT ;
GRIFFIN, DE ;
HIRSCH, RL ;
WOLINSKY, JS ;
ROEDENBECK, S ;
DESORIANO, IL ;
VAISBERG, A .
NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (03) :137-141
[9]   Corticosteroid treatment of experimental autoimmune encephalomyelitis in the Lewis rat results in loss of V beta 8.2(+) and myelin basic protein-reactive cells from the spinal cord, with increased total T-cell apoptosis but reduced apoptosis of V beta 8.2(+) cells [J].
McCombe, PA ;
Nickson, I ;
Tabi, Z ;
Pender, MP .
JOURNAL OF NEUROIMMUNOLOGY, 1996, 70 (02) :93-101
[10]   Apoptosis in measles virus-infected human central nervous system tissues [J].
McQuaid, S ;
McMahon, J ;
Herron, B ;
Cosby, SL .
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1997, 23 (03) :218-224
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