Recent advances in functional assays of transcriptional enhancers

被引：13

作者：

Babbitt, Courtney C. ^{[1
]}

Markstein, Michele ^{[1
]}

Gray, Jesse M. ^{[2
]}

机构：

[1] Univ Massachusetts, Dept Biol, Amherst, MA 01003 USA

[2] Harvard Univ, Sch Med, Dept Genet, Cambridge, MA 02138 USA

来源：

GENOMICS | 2015年 / 106卷 / 03期

关键词：

Enhancers; Cis-regulatory elements; MPRA; STARR-Seq; TRIP; FIREWACh; GENOME; CHROMATIN; EXPRESSION; POSITION; GENE; SEQ;

D O I：

10.1016/j.ygeno.2015.06.002

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In this special edition of Genomics, we present reviews of the current state of the field in identifying and functionally understanding transcriptional enhancers in cells and developing tissues. Typically several enhancers coordinate the expression of an individual target gene, each controlling that gene's expression in specific cell types at specific times. Until recently, identifying each gene's enhancers had been challenging because enhancers do not occupy prescribed locations relative to their target genes. Recently there have been powerful advances in DNA sequencing and other technologies that make it possible to identify the majority of enhancers in virtually any cell type of interest. The reviews in this edition of Genomics highlight some of these new and powerful approaches. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：137 / 139

页数：3

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