UV-curable low-surface-energy fluorinated poly(urethane-acrylate)s for biomedical applications

被引：60

作者：

Lin, Y. H. ^{[1
]}

Liao, K. H. ^{[2
]}

Chou, N. K. ^{[3
]}

Wang, S. S. ^{[3
]}

Chu, S. H. ^{[3
,4
]}

Hsieh, K. H. ^{[1
,2
]}

机构：

[1] Natl Taiwan Univ, Dept Chem Engn, Taipei 10764, Taiwan

[2] Natl Taiwan Univ, Inst Polymer Sci & Engn, Taipei 10764, Taiwan

[3] Natl Taiwan Univ Hosp, Dept Surg, Coll Med, Taipei 100, Taiwan

[4] Far Eastern Mem Hosp, Dept Cardiovasc Surg, Taipei, Taiwan

来源：

EUROPEAN POLYMER JOURNAL | 2008年 / 44卷 / 09期

关键词：

UV-curable; Low-surface-energy; Fluorinated; Poly(urethane-acrylate); Phase separation; Blood compatibility;

D O I：

10.1016/j.eurpolymj.2008.06.030

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Novel UV-curable fluorinated poly(urethane-acrylate) (FPUA) oligomers have been synthesized from 1H,1H,1211,12H-perfluoro-1,12-dodecanediol (PFDDOL), either 1,6-hexamethylene diisocyanate (HDI) or 4,4'-diphenylmethane diisocyanate (M), and 2-hydroxyethyl methacrylate (HEMA) for end-capping with photo-crosslinkable methacrylate groups. The fluorine content and the nature of the isocyanate were investigated to determine their effects on the physical properties, surface properties, and blood compatibilities of the polymers. The introduction of hydrophobic fluorocarbon chains led to phase separation and a low total surface energy, which reduced the adhesion of blood platelets onto the materials. The HDI-type UV-curable, fluorinated poly(urethane-acrylate) exhibited a low-surface-energy and superior blood compatibility (as determined from RIPA values). (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2927 / 2937

页数：11

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