All-trans retinoic acid (ATRA) prevents lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment in aged rats

被引：46

作者：

Behairi, Nassima ^{[1
]}

Belkhelfa, Mourad ^{[1
]}

Rafa, Hayet ^{[1
]}

Labsi, Moussa ^{[1
]}

Deghbar, Nahla ^{[1
]}

Bouzid, Nora ^{[2
]}

Mesbah-Amroun, Hamida ^{[1
]}

Touil-Boukoffa, Chafia ^{[1
]}

机构：

[1] Univ Sci & Technol Houari Boumediene, Fac Biol Sci, Cellular & Mol Biol Lab, Cytokines & Synthases,Immun & Pathogeny Team, BP32 El Alia, Algiers, Algeria

[2] Hammoud Nafissa Hosp, Dept Pathol, Algiers, Algeria

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2016年 / 300卷

关键词：

Aging; All-trans retinoic acid; Alzheimer's disease; Inducible nitric oxide synthase; Neuroinflammation; ALZHEIMERS-DISEASE; EX-VIVO; DIMETHYL-SULFOXIDE; MOUSE MODEL; TNF-ALPHA; IN-VITRO; BRAIN; INFLAMMATION; EXPRESSION; LPS;

D O I：

10.1016/j.jneuroim.2016.10.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We aimed to investigate preventive effects of All-trans retinoic acid (ATRA) on a lipopolysaccharide (LPS)-induced aged neuroinflammation model. We analyzed behavior, systemic nitric oxide (NO) production, cerebral NO synthase (NOS2) and beta-amyloid (A beta) 1-42 expression and tissue integrity in the neuroinflammation model pretreated with ATRA (150 pg/ml/rat/day) for 30 days. Our results showed that LPS treatment (500 mu g/ kg/day) for 7 days disturbed memory, enhanced systemic NO production, NOS2 and A beta 1-42 cerebral expression and generated an Alzheimer's disease (AD)-like neuronal degeneration. Interestingly, ATRA pretreatment prevented the LPS-induced deleterious effects. ATRA could be a potent preventive approach in AD. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：21 / 29

页数：9

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