Computational design and discovery of conformationally flexible inhibitors of acetohydroxyacid synthase to overcome drug resistance associated with the W586L mutation

被引：62

作者：

Ji, Feng-Qin ^{[1
]}

Niu, Cong-Wei ^{[2
]}

Chen, Chao-Nan ^{[1
]}

Chen, Qiong ^{[1
]}

Yang, Guang-Fu ^{[1
]}

Xi, Zhen ^{[2
]}

Zhan, Chang-Guo ^{[3
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China

[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

[3] Univ Kentucky, Coll Pharm, Dept Pharmaceut Sci, Lexington, KY 40536 USA

来源：

CHEMMEDCHEM | 2008年 / 3卷 / 08期

关键词：

enzymes; inhibitors; molecular modeling; rational design;

D O I：

10.1002/cmdc.200800103

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(Figure Presented) Rational design: A series of 2-aroxyl-1,2,4-triazolo[1, 5-c]pyrimidine derivatives were computationally designed (see scheme) and synthesized as conformationally flexible AHAS inhibitors. These compounds could find use as new leads for combating drug resistance. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1203 / 1206

页数：4

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