ZEBRAFISH AS A MODEL SYSTEM TO STUDY TOXICOLOGY

被引：458

作者：

Dai, Yu-Jie ^{[1
]}

Jia, Yong-Fang ^{[2
]}

Chen, Na ^{[1
]}

Bian, Wan-Ping ^{[1
]}

Li, Qin-Kai ^{[1
]}

Ma, Yan-Bo ^{[1
]}

Chen, Yan-Ling ^{[1
]}

Pei, De-Sheng ^{[1
]}

机构：

[1] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Key Lab Reservoir Aquat Environm, Chongqing, Peoples R China

[2] Henan Normal Univ, Coll Life Sci, Xinxiang, Peoples R China

来源：

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY | 2014年 / 33卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Transgenic zebrafish; Environmental pollution; Monitoring; Model system; Toxicology; DANIO-RERIO; BISPHENOL-A; IN-VIVO; TRANSGENIC ZEBRAFISH; GENE-EXPRESSION; DNA-DAMAGE; PERMETHRIN ENANTIOMERS; DEVELOPMENTAL TOXICITY; OXIDATIVE STRESS; METHYL PARATHION;

D O I：

10.1002/etc.2406

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Monitoring and assessing the effects of contaminants in the aquatic eco-environment is critical in protecting human health and the environment. The zebrafish has been widely used as a prominent model organism in different fields because of its small size, low cost, diverse adaptability, short breeding cycle, high fecundity, and transparent embryos. Recent studies have demonstrated that zebrafish sensitivity can aid in monitoring environmental contaminants, especially with the application of transgenic technology in this area. The present review provides a brief overview of recent studies on wild-type and transgenic zebrafish as a model system to monitor toxic heavy metals, endocrine disruptors, and organic pollutants for toxicology. The authors address the new direction of developing high-throughput detection of genetically modified transparent zebrafish to open a new window for monitoring environmental pollutants. Environ Toxicol Chem 2014;33:11-17. (c) 2013 SETAC

引用

页码：11 / 17

页数：7

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