Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines

被引：72
|
作者：
Bai, NS
Lai, CS
He, K
Zhou, Z
Zhang, L
Quan, Z
Zhu, NQ
Zheng, QY
Pan, MH
Ho, CT
机构：
[1] Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA
[2] Natl Kaohsiung Marine Univ, Dept Seafood Sci, Kaohsiung, Taiwan
[3] PureWorld Bot Inc, S Hackensack, NJ 07606 USA
[4] Fudan Univ, Coll Pharm, Shanghai 200032, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 04期
关键词：
D O I：
10.1021/np050437q
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three new sesquiterpenes (1-3), together with four known sesquiterpene lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All sesquiterpene lactones were tested for cytotoxicity as well as apoptotic ratio in human COLO 205, HT 29, HL-60, and AGS cancer cells. Compounds 3 and 4, two alpha-methylene gamma-lactone-bearing sesquiterpenes, were modestly active in these assays.
引用
收藏
页码：531 / 535
页数：5
相关论文
共 50 条
  • [1] Cytotoxic activity of sesquiterpene lactones from Inula britannica on human cancer cell lines
    Fischedick, Justin T.
    Pesic, Milica
    Podolski-Renic, Ana
    Bankovic, Jasna
    de Vos, Ric C. H.
    Peric, Marija
    Todorovic, Slapana
    Tanic, Nikola
    PHYTOCHEMISTRY LETTERS, 2013, 6 (02) : 246 - 252
  • [2] Cytotoxic sesquiterpene lactones from Inula britannica
    Park, EJ
    Kim, J
    PLANTA MEDICA, 1998, 64 (08) : 752 - 754
  • [3] Cytotoxic and Pro-apoptotic Activities of Sesquiterpene Lactones from Inula britannica
    Xiang, Ping
    Guo, Xin
    Han, Yang-Yang
    Gao, Jin-Ming
    Tang, Jiang-Jiang
    NATURAL PRODUCT COMMUNICATIONS, 2016, 11 (01) : 7 - 10
  • [4] SESQUITERPENE LACTONES FROM INULA-BRITANNICA
    ZHOU, BN
    BAI, NS
    LIN, LZ
    CORDELL, GA
    PHYTOCHEMISTRY, 1993, 34 (01) : 249 - 252
  • [5] Three new sesquiterpene lactones from Inula britannica
    Zhang, Xu-Feng
    Du, Jing-Ling
    Ren, Jie
    Ye, Feng-Mei
    Xie, Yang-Guo
    Cheng, Xiang-Rong
    Yan, Shi-Kai
    Jin, Hui-Zi
    ARCHIVES OF PHARMACAL RESEARCH, 2015, 38 (05) : 666 - 672
  • [6] Three new sesquiterpene lactones from Inula britannica
    Bai, NS
    Zhou, BN
    Zhang, L
    Sang, SM
    He, K
    Zheng, QY
    ORIENTAL FOODS AND HERBS: CHEMISTRY AND HEALTH EFFECTS, 2003, 859 : 271 - 278
  • [7] Sesquiterpene lactones from the aerial parts of Xanthium sibiricum and their cytotoxic effects on human cancer cell lines
    Bui, Van-Binh
    Liu, Shu-Ting
    Zhu, Jing-Jing
    Xiong, Juan
    Zhao, Yun
    Yang, Guo-Xun
    Xia, Gang
    Hu, Jin-Feng
    PHYTOCHEMISTRY LETTERS, 2012, 5 (03) : 685 - 689
  • [8] 7 SESQUITERPENE LACTONES FROM INULA-BRITANNICA VAR CHINENSIS
    ITO, K
    IDA, T
    PHYTOCHEMISTRY, 1981, 20 (02) : 271 - 273
  • [9] Isolation of new sesquiterpene lactones from Inula britannica with centrifugal partition chromatography
    Fischedick, J.
    PLANTA MEDICA, 2012, 78 (11) : 1214 - 1214
  • [10] New Sesquiterpene Lactones from Glechoma hederacea L. and Their Cytotoxic Effects on Human Cancer Cell Lines
    Kim, JinPyo
    Lee, IkSoo
    Ha, DoThi
    Seo, JeongJu
    Min, ByungSun
    Yoo, IckDong
    Bae, KiHwan
    PLANTA MEDICA, 2011, 77 (09) : 955 - 957
12345