Selective solid-phase iodination of phenolic groups with bis(pyridine)iodonium (I) tetrafluoroborate

被引：10
作者：
Arsequell, G
Espuña, G
Valencia, G
Barluenga, J
Carlón, RP
González, JM
机构：
[1] CSIC, IIQAB, Unit Glycoconjugate Chem, E-08034 Barcelona, Spain
[2] Univ Oviedo, CSIC, Inst Quim Organomet Enrique Moles, Unidad Asociada, E-33071 Oviedo, Spain
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 40期
关键词：
halogenation; biologically active compounds; protecting groups; supported reagents/reactions;
D O I：
10.1016/S0040-4039(99)01522-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Selective direct aromatic electrophilic iodination of target phenol groups can be performed by the IPy2BF4 reagent on multiple phenol containing substrates while anchored on solid supports. The tactics make use of orthogonal protecting groups capable of inhibiting the reaction of the untargeted phenol. Suitable groups are of ether and silyl type. The methodology has been demonstrated on a biomolecule such as dermorphin where the integrity of one of two phenol functions is crucial for its biological activity. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7279 / 7282
页数：4
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