Molecular recognition study of ethosuximide by the supramolecular probe, p-t-butyl calix(8)arene

被引:4
作者
Meenakshi, C. [1 ]
Sangeetha, P. [2 ]
Ramakrishnan, V. [2 ]
机构
[1] Shri Meenakshi Govt Coll Women Autonomous, Dept Chem, Madurai 625002, Tamil Nadu, India
[2] Madurai Kamaraj Univ, Sch Phys, Dept Laser Studies, Madurai 625021, Tamil Nadu, India
关键词
Ethosuximide; Antiseizure drug molecule; Supra molecule; p-t-Butyl calix(8)arene; Molecular recognition; CALIXARENES; COMPLEXES; INCLUSION; DERIVATIVES; GUESTS;
D O I
10.1016/j.jlumin.2012.12.055
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
The supramolecule, p-t-Butyl calix(8)arene, forms inclusion complex with the antiseizure drug molecule, ethosuximide. This feature is explained on the basis of optical absorption spectroscopy. Here p-t-Butyl calix(8)arene is the host molecule and ethosuximide is the guest molecule. The stoichiometry of the host-guest complex and the binding constant has been determined using Benesi-Hildebrand plot. Based on the result obtained the structure of the inclusion complex has been proposed. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:129 / 132
页数:4
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