The Effect of Sperm DNA Fragmentation on Male Fertility and Strategies for Improvement: A Narrative Review

被引：7
作者：
Loloi, Justin
Petrella, Francis
Kresch, Eliyahu
Ibrahim, Emad
Zini, Armand
Ramasamy, Ranjith [1 ]
机构：
[1] Albert Einstein Coll Med, Montefiore Med Ctr, Dept Urol, Bronx, NY 10461 USA
来源：
UROLOGY | 2022年 / 168卷
关键词：
CHROMATIN-STRUCTURE ASSAY; INTRACYTOPLASMIC SPERM; VARICOCELE REPAIR; PREGNANCY LOSS; LIVE BIRTH; DAMAGE; MEN; INFERTILITY; ICSI; INJECTION;
D O I：
10.1016/j.urology.2022.05.036
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The inability to conceive due to male infertility is a complex issue with a wide variety of etiologies. Sperm DNA damage can be both a barrier to natural pregnancy and successful assisted reproductive technology (ART). The aim of this narra-tive review was to describe and highlight the effects of sperm DNA fragmentation and the most recent data on various treatment strategies to decrease sperm DNA damage. Finally, we proposed a management algorithm for couples undergo-ing ART with increased sperm DNA fragmentation. UROLOGY 168: 3-9, 2022.(c) 2022 Elsevier Inc.
引用
收藏
页码：3 / 9
页数：7
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