Antihyperglycemic and antioxidant activity of water extract from Anoectochilus roxburghii in experimental diabetes

被引：84

作者：

Cui, Shi-Chao ^{[1
]}

Yu, Jie ^{[1
]}

Zhang, Xiao-Hui ^{[1
]}

Cheng, Mei-Zhen ^{[1
]}

Yang, La-Wei ^{[1
]}

Xu, Jing-Yan ^{[1
]}

机构：

[1] Shantou Univ, Dept Biol, Shantou 515063, Guangdong, Peoples R China

来源：

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 2013年 / 65卷 / 05期

关键词：

Anoectochilus roxburghii; Hypoglycemic; Antioxidant; Alloxan-induced diabetic mice; Water extract; LIPID-PEROXIDATION; OXIDATIVE STRESS; PARAMETERS;

D O I：

10.1016/j.etp.2012.02.003

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The hypoglycemic and antioxidant effects of the water extract from Anoectochilus roxburghii in alloxan-induced diabetic mice were examined. Compared with untreated diabetic mice, the daily oral administration of the water extract from A. roxburghii at 0.5 or 2 g/kg for 14 days caused a significant decrease (p<.05) in blood glucose levels with similar effect but no evidence of dose-related effect. Simultaneously, the alteration in lipid metabolism was partially attenuated as evidenced by decreased serum total cholesterol and triglyceride levels and by increased high-density lipoprotein cholesterol concentration in diabetic mice (p<.05) but no dose-related effect was observed. In addition, the water extract from A. roxburghii caused a significant increase (p<.05) in the activities of enzymic antioxidants and the levels of vitamin E in liver and kidney of diabetic mice. Our results suggest that water extract from A. roxburghii possesses hypoglycemic and antioxidant properties after oral administration to mice showing alloxan-induced diabetes. (C) 2012 Elsevier GmbH. All rights reserved.

引用

页码：485 / 488

页数：4

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