Microwave-Assisted Synthesis of Ethyl 1,3-Disubstituted-1,6-dihydropyrrolo[2,3-c]pyrazole-5-carboxylates

被引：5

作者：

Gu, Lijun ^{[1
,2
]}

Li, Xiangguang ^{[3
]}

机构：

[1] Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650500, Yunnan, Peoples R China

[2] Yunnan Univ Nationalities, Minist Educ, Kunming 650500, Yunnan, Peoples R China

[3] NW Univ Xian, Dept Chem, Xian 710069, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2013年 / 50卷 / 02期

关键词：

pyrazole; Synthesis; Microwave irradiation; BIOLOGICAL-ACTIVITY; DERIVATIVES; INHIBITORS;

D O I：

10.1002/jhet.1115

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel series of ethyl 1,3-disubstituted-1,6-dihydropyrrolo[2,3-c]pyrazole-5-carboxylates can be rapidly and efficiently synthesized in excellent yields by condensing a variety of 1,3-substituted-4-formyl-5-chloropyrazole with ethyl isocyanoacetate in the presence of 1-methyl-3-butylimidazolium hydroxide under microwave irradiation. The simple experimental procedure, DMSO-free condition, short period of conversion, and excellent yields are the advantages of the present method. The structures of the novel compounds are confirmed by IR, 1H NMR, 13C NMR, MALDI-TOF MS, and elemental analysis.

引用

页码：408 / 412

页数：5

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