Expression of Stromal Cell-Derived Factor 1 and CXCR7 in Papillary Thyroid Carcinoma

被引：34

作者：

Liu, Zhen ^{[1
]}

Sun, Da-Xin ^{[1
]}

Teng, Xu-Yong ^{[1
]}

Xu, Wei-Xue ^{[1
]}

Meng, Xiang-Peng ^{[1
]}

Wang, Bao-Sheng ^{[1
]}

机构：

[1] China Med Univ, Dept Gen Surg, Shengjing Hosp, Shenyang 110004, Peoples R China

来源：

ENDOCRINE PATHOLOGY | 2012年 / 23卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Thyroid neoplasms; Chemokine; SDF-1; Chemokine receptors; CXCR7; CHEMOKINE RECEPTOR CXCR7; LYMPH-NODE METASTASIS; FACTOR-I; TUMOR-GROWTH; HEPATOCELLULAR-CARCINOMA; PROGENITOR CELLS; T-LYMPHOCYTES; MICE LACKING; LUNG-CANCER; MIGRATION;

D O I：

10.1007/s12022-012-9223-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stromal cell-derived factor 1 (SDF-1) is a chemokine that is expressed in some cancer cells and is involved in tumor cell migration and metastasis. CXCR7, a novel receptor for SDF-1, has been identified recently. Researches demonstrated that interaction between SDF-1 and CXCR7 could play an important role in cancer progression. In this study, we aimed to investigate the expressions of SDF-1 and CXCR7 and the relationship between their expressions and clinicopathological characteristics in papillary thyroid carcinoma (PTC). Expressions of SDF-1 and CXCR7 in 33 cases of thyroid benign lesion tissue and 79 cases of PTC tissue and peritumoral non-malignant tissue were detected by immunohistochemical staining. Expressions of SDF-1 and CXCR7 were negative in peritumoral non-malignant tissues. Respectively, positive expression rates of SDF-1 and CXCR7 were 69.6 and 65.8 % in PTC, 12.1 and 30.3 % in thyroid benign tissue. The expression of SDF-1 and CXCR7 were positively correlated with lymph node metastasis. SDF-1 and CXCR7 expressions were related with the lymph nodes metastasis of PTC.

引用

页码：247 / 253

页数：7

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