Insulin Resistance and Heart Failure: Molecular Mechanisms

被引：187

作者：

Aroor, Annayya R. ^{[1
,2
]}

Mandavia, Chirag H. ^{[1
,2
]}

Sowers, James R. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Missouri, Sch Med, Dept Internal Med, Columbia, MO 65212 USA

[2] Univ Missouri, Diabet & Cardiovasc Res Ctr, Sch Med, Columbia, MO 65212 USA

[3] Univ Missouri, Dept Med Pharmacol & Physiol, Sch Med, Columbia, MO 65212 USA

[4] Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA

来源：

HEART FAILURE CLINICS | 2012年 / 8卷 / 04期

关键词：

Cardiac insulin resistance; Cardiorenal metabolic syndrome; Heart failure; Molecular mechanisms; ENDOPLASMIC-RETICULUM STRESS; MUSCLE GLUCOSE-TRANSPORT; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; RENIN INHIBITION; OBESITY; METABOLISM; TARGET; ALDOSTERONE; SENSITIVITY;

D O I：

10.1016/j.hfc.2012.06.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This article addresses the issue of insulin resistance and associated reductions in cardiac insulin metabolic signaling, which is emerging as a major factor in the development of heart failure, and assumes more importance because of an epidemic increase in obesity and the cardiorenal metabolic syndrome in our aging population. The effects of cardiac insulin resistance are exacerbated by metabolic, endocrine, and cytokine alterations associated with systemic insulin resistance. Understanding the molecular mechanisms linking insulin resistance and heart failure may help to design new and more effective mechanism-based drugs to improve myocardial and systemic insulin resistance.

引用

页码：609 / +

页数：10

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