The breast cancer susceptibility-related polymorphisms at the TOX3/LOC643714 locus associated with lung cancer risk in a Han Chinese population

被引：11

作者：

Jiang, Chaowen ^{[1
]}

Yu, Shilong ^{[1
]}

Qian, Pin ^{[1
]}

Guo, Ruiling ^{[2
]}

Zhang, Ruijie ^{[3
]}

Ao, Zhi ^{[1
]}

Li, Qi ^{[1
]}

Wu, Guoming ^{[1
]}

Chen, Yan ^{[1
]}

Li, Jin ^{[1
]}

Wang, Changzheng ^{[1
]}

Yao, Wei ^{[1
]}

Xu, Jiancheng ^{[1
]}

Qian, Guisheng ^{[1
]}

Ji, Fuyun ^{[1
]}

机构：

[1] Third Mil Med Univ, Xinqiao Hosp, Inst Human Resp Dis, Chongqing 400037, Peoples R China

[2] PLA, Hosp 324, Dept Resp Dis, Chongqing 400020, Peoples R China

[3] Cent S Univ, Xiangya Hosp 3, Dept Resp Med, Changsha 410013, Hunan, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 37期

基金：

中国国家自然科学基金;

关键词：

lung cancer; risk; TOX3/LOC643714; polymorphisms; breast cancer; GENOME-WIDE ASSOCIATION; GENETIC-VARIANTS; WOMEN; TRANSCRIPTION; MOVEMENTS; MUTATION; BRCA2; TOX3;

D O I：

10.18632/oncotarget.10874

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It has been well established that besides environmental factors, genetic factors are also associated with lung cancer risk. However, to date, the prior identified genetic variants and loci only explain a small fraction of the familial risk of lung cancer. Hence it is vital to investigate the remaining missing heritability to understand the development and process of lung cancer. In the study, to test our hypothesis that the previously identified breast cancer risk-associated genetic polymorphisms at the TOX3/LOC643714 locus might contribute to lung cancer risk, 16 SNPs at the TOX3/LOC643714 locus were evaluated in a Han Chinese population based on a case-control study. Pearson's chi-square test or Fisher's exact test revealed that rs9933638, rs12443621, and rs3104746 were significantly associated with lung cancer risk (P < 0.001, P < 0.001, and P = 0.005, respectively). Logistic regression analyses displayed that lung cancer risk of individuals with rs9933638(GG+GA) were 1.89 times higher than that of rs9933638AA carriers (OR = 1.893, 95% CI = 1.308-2.741, P = 0.001). Similar findings were manifested for rs12443621 (OR = 1.824, 95% CI = 1.272-2.616, P = 0.001, rs12443621(GG+GA) carriers vs. rs12443621AA carriers) and rs3104746 (OR = 1.665, 95% CI = 1.243-2.230, P = 0.001, rs3104746TT carriers vs. rs3104746(TA+AA) carriers). The study discovered for the first time that three SNPs (rs9933638, rs12443621, and rs3104746) at the TOX3/LOC643714 locus contributed to lung cancer risk, providing new evidences that lung cancer and breast cancer are linked at the molecular and genetic level to a certain extent.

引用

页码：59742 / 59753

页数：12

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