The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1

被引：31
作者：
Karrich, Julien J. [1 ]
Balzarolo, Melania [2 ,3 ]
Schmidlin, Heike [1 ]
Libouban, Marion [1 ]
Nagasawa, Maho [1 ]
Gentek, Rebecca [1 ]
Kamihira, Shimeru [4 ]
Maeda, Takahiro [5 ]
Amsen, Derk [1 ]
Wolkers, Monika C. [2 ,3 ]
Blom, Bianca [1 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Ctr Expt Mol Med, Lab Expt Oncol & Radiobiol, NL-1105 AZ Amsterdam, Netherlands
[3] Univ Amsterdam, Dept Hematopoiesis, Sanquin Res Landsteiner Lab AMC, Amsterdam, Netherlands
[4] Nagasaki Univ, Grad Sch Biomed Sci, Dept Lab Med, Nagasaki 852, Japan
[5] Nagasaki Univ, Grad Sch Biomed Sci, Isl Med Res Inst, Dept Isl & Community Med, Nagasaki 852, Japan
来源：
BLOOD | 2012年 / 119卷 / 22期
关键词：
NF-KAPPA-B; BCL-2; HOMOLOG; INDUCED APOPTOSIS; FACTORS PU.1; IN-VIVO; FACTOR E2-2; HUMAN A1; T-CELL; C-REL; EXPRESSION;
D O I：
10.1182/blood-2011-07-370239
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Plasmacytoid dendritic cells (pDCs) selectively express Toll-like receptor (TLR)-7 and TLR-9, which allow them to rapidly secrete massive amounts of type I interferons after sensing nucleic acids derived from viruses or bacteria. It is not completely understood how development and function of pDCs are controlled at the transcriptional level. One of the main factors driving pDC development is the ETS factor Spi-B, but little is known about its target genes. Here we demonstrate that Spi-B is crucial for the differentiation of hematopoietic progenitor cells into pDCs by controlling survival of pDCs and its progenitors. In search for Spi-B target genes, we identified the antiapoptotic gene Bcl2-A1 as a specific and direct target gene, thereby consolidating the critical role of Spi-B in cell survival. (Blood. 2012; 119(22): 5191-5200)
引用
收藏
页码：5191 / 5200
页数：10
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