Diabetes - Fat in all the wrong places

被引:88
作者
Friedman, J [1 ]
机构
[1] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA
关键词
D O I
10.1038/415268a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Obesity and a rare, congenital absence of fat cells are associated with damaging levels of fat in various tissues, and diabetes. Leptin helps to remedy these problems by causing oxidation of fatty acids in mitochondria.
引用
收藏
页码:268 / 269
页数:2
相关论文
共 18 条
[1]   Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2 [J].
Abu-Elheiga, L ;
Matzuk, MM ;
Abo-Hashema, KAH ;
Wakil, SJ .
SCIENCE, 2001, 291 (5513) :2613-2616
[2]  
Friedman J M, 1999, Harvey Lect, V95, P107
[3]   Recombinant leptin for weight loss in obese and lean adults - A randomized, controlled, dose-escalation trial [J].
Heymsfield, SB ;
Greenberg, AS ;
Fujioka, K ;
Dixon, RM ;
Kushner, R ;
Hunt, T ;
Lubina, JA ;
Patane, J ;
Self, B ;
Hunt, P ;
McCamish, M .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (16) :1568-1575
[4]   Acute stimulation of glucose metabolism in mice by leptin treatment [J].
Kamohara, S ;
Burcelin, R ;
Halaas, JL ;
Friedman, JM ;
Charron, MJ .
NATURE, 1997, 389 (6649) :374-377
[5]   WHAT IF MINKOWSKI HAD BEEN AGEUSIC - AN ALTERNATIVE ANGLE ON DIABETES [J].
MCGARRY, JD .
SCIENCE, 1992, 258 (5083) :766-770
[6]   POSSIBLE ROLE FOR MALONYL-COA IN REGULATION OF HEPATIC FATTY-ACID OXIDATION AND KETOGENESIS [J].
MCGARRY, JD ;
MANNAERTS, GP ;
FOSTER, DW .
JOURNAL OF CLINICAL INVESTIGATION, 1977, 60 (01) :265-270
[7]   Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase [J].
Minokoshi, Y ;
Kim, YB ;
Peroni, OD ;
Fryer, LGD ;
Müller, C ;
Carling, D ;
Kahn, BB .
NATURE, 2002, 415 (6869) :339-343
[8]   EFFECTS OF THE OBESE GENE-PRODUCT ON BODY-WEIGHT REGULATION IN OB/OB MICE [J].
PELLEYMOUNTER, MA ;
CULLEN, MJ ;
BAKER, MB ;
HECHT, R ;
WINTERS, D ;
BOONE, T ;
COLLINS, F .
SCIENCE, 1995, 269 (5223) :540-543
[9]  
Randle PJ, 1998, DIABETES METAB REV, V14, P263, DOI 10.1002/(SICI)1099-0895(199812)14:4&lt
[10]  
263::AID-DMR233&gt