Kidney-targeted astaxanthin natural antioxidant nanosystem for diabetic nephropathy therapy

被引：49

作者：

Chen, Zhong ^{[1
]}

Li, Wenhua ^{[1
]}

Shi, Liwang ^{[1
]}

Jiang, Lei ^{[1
]}

Li, Minghui ^{[1
]}

Zhang, Changmei ^{[1
]}

Peng, Haisheng ^{[1
]}

机构：

[1] Harbin Med Univ, Dept Pharmaceut, Daqing Campus,1 Xinyang Rd, Daqing 163319, Peoples R China

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2020年 / 156卷

关键词：

Astaxanthin; Liposome; Kidney-targeted; Diabetic nephropathy; Oxidative stress; GLUT1; INDUCED OXIDATIVE STRESS; MESANGIAL CELLS; GLUT1; EXPRESSION; GLUCOSE-UPTAKE; OVEREXPRESSION; CAROTENOIDS; STABILITY; REVERSES; MODELS; SIZE;

D O I：

10.1016/j.ejpb.2020.09.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Diabetic nephropathy (DN) is a frequent and severe microvascular complication associated with oxidative stress of diabetes mellitus. A novel astaxanthin-based natural antioxidant nanosystem, namely AST-GLU-LIP, with preferential renal uptake and bioavailability were prepared and applied for treatment of diabetic nephropathy in rats. Our results of kidney-targeted evaluation showed that glucose-PEG(600)-DSPE ligand modified AST liposomes could be specifically transported by overexpressed GLUT1 on the membrane of glomerular mesangial cells and achieved excellent kidney-targeted drug delivery. In addition, the results of pharmacodynamics and therapeutics in DN rats demonstrated that AST-GLU-LIP could improve the bioavailability and antioxidant capacity of AST to scavenge redundant ROS induced by oxidative stress. AST-GLU-LIP could also significantly improve the renal pathological morphology to protect the kidney as a therapeutic drug for diabetic nephropathy.

引用

页码：143 / 154

页数：12

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