Preclinical Mouse Cancer Models: A Maze of Opportunities and Challenges

被引：455

作者：

Day, Chi-Ping ^{[1
]}

Merlino, Glenn ^{[1
]}

Van Dyke, Terry ^{[2
]}

机构：

[1] NCI, Lab Canc Biol & Genet, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[2] NCI, Ctr Adv Preclin Res, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

CELL | 2015年 / 163卷 / 01期

关键词：

CELL LUNG-CANCER; GROWTH-FACTOR RECEPTOR; IN-VIVO; TUMOR XENOGRAFTS; CLINICAL-RESPONSE; SURVIVAL BENEFIT; DRUG-RESISTANCE; RETINOIC ACID; MICE; PATHWAY;

D O I：

10.1016/j.cell.2015.08.068

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Significant advances have been made in developing novel therapeutics for cancer treatment, and targeted therapies have revolutionized the treatment of some cancers. Despite the promise, only about five percent of new cancer drugs are approved, and most fail due to lack of efficacy. The indication is that current preclinical methods are limited in predicting successful outcomes. Such failure exacts enormous cost, both financial and in the quality of human life. This Primer explores the current status, promise, and challenges of preclinical evaluation in advanced mouse cancer models and briefly addresses emerging models for early-stage preclinical development.

引用

页码：39 / 53

页数：15

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