Renal aspirin: will all patients with chronic kidney disease one day take spironolactone?

被引：21

作者：

Bomback, Andrew S. ^{[1
]}

Kshirsagar, Abhijit V. ^{[1
]}

Klemmer, Philip J. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Med, Div Nephrol & Hypertens, Chapel Hill, NC USA

来源：

NATURE CLINICAL PRACTICE NEPHROLOGY | 2009年 / 5卷 / 02期

关键词：

CHRONIC CYCLOSPORINE NEPHROTOXICITY; PLASMA-ALDOSTERONE; METABOLIC SYNDROME; BLOCKADE;

D O I：

10.1038/ncpneph1004

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The role of aldosterone in the progression of kidney dysfunction, via its actions on mineralocorticoid receptors, is increasingly recognized. The authors of this Viewpoint outline the beneficial effects that have been seen in animal and human studies of mineralocorticoid receptor blockade in various forms of kidney disease. They predict that low daily doses of the aldosterone blocker spironolactone—an inexpensive, generic medication with few and easily recognizable adverse effects—might one day become the renal equivalent of 'baby' aspirin.

引用

页码：74 / 75

页数：2

共 11 条

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