ACUTE CAFFEINE ADMINISTRATION IMPACT ON WORKING MEMORY-RELATED BRAIN ACTIVATION AND FUNCTIONAL CONNECTIVITY IN THE ELDERLY: A BOLD AND PERFUSION MRI STUDY

被引：35
作者：
Haller, S. [1 ,2 ]
Rodriguez, C. [2 ,3 ]
Moser, D. [1 ,2 ]
Toma, S. [2 ,3 ]
Hofmeister, J. [2 ,3 ]
Sinanaj, I. [2 ,3 ]
Van De Ville, D. [4 ,5 ]
Giannakopoulos, P. [2 ,3 ]
Lovblad, K. -O. [1 ,2 ]
机构：
[1] Univ Hosp Geneva, Dept Imaging & Med Informat, CH-1211 Geneva 14, Switzerland
[2] Univ Geneva, Fac Med, CH-1211 Geneva 4, Switzerland
[3] Univ Hosp Geneva, Dept Mental Hlth & Psychiat, CH-1211 Geneva 14, Switzerland
[4] Univ Geneva, Dept Radiol & Med Informat, CH-1211 Geneva 4, Switzerland
[5] Ecole Polytech Fed Lausanne, Inst Bioengn, CH-1015 Lausanne, Switzerland
来源：
NEUROSCIENCE | 2013年 / 250卷
关键词：
fMRI; BOLD; caffeine; cognition; aging; INDEPENDENT COMPONENT ANALYSIS; CEREBRAL-BLOOD-FLOW; OXYGEN-METABOLISM; FMRI; DEMENTIA; SIGNAL; STATE; INFERENCE; LOCALIZATION; PSYCHOMOTOR;
D O I：
10.1016/j.neuroscience.2013.07.021
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In young individuals, caffeine-mediated blockade of adenosine receptors and vasoconstriction has direct repercussions on task-related activations, changes in functional connectivity, as well as global vascular effects. To date, no study has explored the effect of caffeine on brain activation patterns during highly demanding cognitive tasks in the elderly. This prospective, placebo-controlled crossover design comprises 24 healthy elderly individuals (mean age 68.8 +/- 4.0 years, 17 females) performing a 2-back working memory (WM) task in functional magnetic resonance imaging (fMRI). Analyses include complimentary assessment of task-related activations (general linear model, GLM), functional connectivity (tensorial independent component analysis, TICA), and baseline perfusion (arterial spin labeling). Despite a reduction in whole-brain global perfusion (-22.7%), caffeine-enhanced task-related GLM activation in a local and distributed network is most pronounced in the bilateral striatum and to a lesser degree in the right middle and inferior frontal gyrus, bilateral insula, left superior and inferior parietal lobule as well as in the cerebellum bilaterally. TICA was significantly enhanced (+8.2%) in caffeine versus placebo in a distributed and task-relevant network including the pre-frontal cortex, the supplementary motor area, the ventral premotor cortex and the parietal cortex as well as the occipital cortex (visual stimuli) and basal ganglia. The inverse comparison of placebo versus caffeine had no significant difference. Activation strength of the task-relevant-network component correlated with response accuracy for caffeine yet not for placebo, indicating a selective cognitive effect of caffeine. The present findings suggest that acute caffeine intake enhances WM-related brain activation as well as functional connectivity of blood oxygen level-dependent fMRI in elderly individuals. (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：364 / 371
页数：8
相关论文
共 50 条
[21]   Perfusion Deficits and Functional Connectivity Alterations in Memory-Related Regions of Patients with Post-Traumatic Stress Disorder [J].
Liu, Yang ;
Li, Baojuan ;
Feng, Na ;
Pu, Huangsheng ;
Zhang, Xi ;
Lu, Hongbing ;
Yin, Hong .
PLOS ONE, 2016, 11 (05)
[22]   Alteration of functional connectivity within visuospatial working memory-related brain network in patients with right temporal lobe epilepsy: A resting-state fMRI study [J].
Lv, Zong-xia ;
Huang, Dong-hong ;
Ye, Wei ;
Chen, Zi-rong ;
Huang, Wen-li ;
Zheng, Jin-ou .
EPILEPSY & BEHAVIOR, 2014, 35 :64-71
[23]   Altered working memory-related brain activity in children at familial high risk for psychosis: A preliminary study [J].
Gool, Kevin C. A. van ;
Collin, Guusje ;
Bauer, Clemens C. C. ;
Molokotos, Elena ;
Mesholam-Gately, Raquelle I. ;
Thermenos, Heidi W. ;
Seidman, Larry J. ;
Gabrieli, John D. E. ;
Whitfield-Gabrieli, Susan ;
Keshavan, Matcheri S. .
SCHIZOPHRENIA RESEARCH, 2022, 240 :186-192
[24]   A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene [J].
Papassotiropoulos, A. ;
Stefanova, E. ;
Vogler, C. ;
Gschwind, L. ;
Ackermann, S. ;
Spalek, K. ;
Rasch, B. ;
Heck, A. ;
Aerni, A. ;
Hanser, E. ;
Demougin, P. ;
Huynh, K-D ;
Luechinger, R. ;
Klarhoefer, M. ;
Novakovic, I. ;
Kostic, V. ;
Boesiger, P. ;
Scheffler, K. ;
de Quervain, D. J-F .
MOLECULAR PSYCHIATRY, 2013, 18 (02) :255-263
[25]   Age-related differences in brain activation during working memory updating: An fMRI study [J].
Qin, Shuo ;
Basak, Chandramallika .
NEUROPSYCHOLOGIA, 2020, 138
[26]   General intelligence is associated with working memory-related brain activity: new evidence from a large sample study [J].
Takeuchi, Hikaru ;
Taki, Yasuyuki ;
Nouchi, Rui ;
Yokoyama, Ryoichi ;
Kotozaki, Yuka ;
Nakagawa, Seishu ;
Sekiguchi, Atsushi ;
Iizuka, Kunio ;
Hanawa, Sugiko ;
Araki, Tsuyoshi ;
Miyauchi, Carlos Makoto ;
Sakaki, Kohei ;
Sassa, Yuko ;
Nozawa, Takayuki ;
Ikeda, Shigeyuki ;
Yokota, Susumu ;
Daniele, Magistro ;
Kawashima, Ryuta .
BRAIN STRUCTURE & FUNCTION, 2018, 223 (09) :4243-4258
[27]   Changes in brain activation associated with use of a memory strategy: a functional MRI study [J].
Kondo, Y ;
Suzuki, M ;
Mugikura, S ;
Abe, N ;
Takahashi, S ;
Iijima, T ;
Fujii, T .
NEUROIMAGE, 2005, 24 (04) :1154-1163
[28]   An event-related functional MRI study of working memory in euthymic bipolar disorder [J].
Lagopoulos, Jim ;
Ivanovski, Belinda ;
Malhi, Gin S. .
JOURNAL OF PSYCHIATRY & NEUROSCIENCE, 2007, 32 (03) :174-184
[29]   Functional MRI Study of Gender Effects in Brain Activations During Verbal Working Memory Task [J].
Tudos, Z. ;
Hok, P. ;
Hlustik, P. ;
Grambal, A. .
PHYSIOLOGICAL RESEARCH, 2018, 67 (05) :825-829
[30]   A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene [J].
A Papassotiropoulos ;
E Stefanova ;
C Vogler ;
L Gschwind ;
S Ackermann ;
K Spalek ;
B Rasch ;
A Heck ;
A Aerni ;
E Hanser ;
P Demougin ;
K-D Huynh ;
R Luechinger ;
M Klarhöfer ;
I Novakovic ;
V Kostic ;
P Boesiger ;
K Scheffler ;
D J-F de Quervain .
Molecular Psychiatry, 2013, 18 :255-263
12345