Diabetes Mellitus-Associated Vascular Impairment Novel Circulating Biomarkers and Therapeutic Approaches

被引：221

作者：

Tousoulis, Dimitris ^{[1
]}

Papageorgiou, Nikolaos ^{[1
]}

Androulakis, Emmanuel ^{[1
]}

Siasos, Gerasimos ^{[1
]}

Latsios, George ^{[1
]}

Tentolouris, Konstantinos ^{[1
]}

Stefanadis, Christodoulos ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Hippokrat Hosp, Cardiol Dept 1, Athens 11528, Greece

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2013年 / 62卷 / 08期

关键词：

biomarkers; diabetes mellitus; endothelium; vascular function; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; OXIDE-SYNTHASE GENE; ENDOTHELIAL PROGENITOR CELLS; ACUTE CORONARY SYNDROMES; OXIDATIVE STRESS; NITRIC-OXIDE; MYOCARDIAL-INFARCTION; ASYMMETRIC DIMETHYLARGININE; CARDIOVASCULAR-DISEASE;

D O I：

10.1016/j.jacc.2013.03.089

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is widely accepted that diabetes mellitus (DM) impairs endothelial nitric oxide synthase activity as well as enhances the production of reactive oxygen species, thus resulting in diminished nitric oxide bioavailability and the consequent pro-atherogenetic alterations. Important biomarkers of the vasculature are related to endothelial dysfunction, to inflammatory and coagulation processes, and to oxidative stress in DM. Several therapeutic strategies might exert favorable effects on the vasculature of diabetic patients, such as insulin analogues, antihypertensive agents, statins, and hypoglycemic agents, whereas in spite of the prominent role of oxidative stress in diabetes, antioxidant therapy remains controversial. The use of specific biomarkers related to vascular function could be a useful therapeutic approach in such patients. (C) 2013 by the American College of Cardiology Foundation

引用

页码：667 / 676

页数：10

共 80 条

[51] Osteoprotegerin gene rs2073617 and rs3134069 polymorphisms in type 2 diabetes patients and sex-specific rs2073618 polymorphism as a risk factor for diabetic foot [J].

Nehring, Piotr ;

Mrozikiewicz-Rakowska, Beata ;

Sobczyk-Kopciol, Agnieszka ;

Makowski, Adam ;

Krasnodebski, Przemyslaw ;

Ploski, Rafal ;

Broda, Grazyna ;

Karnafel, Waldemar .

POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ-POLISH ARCHIVES OF INTERNAL MEDICINE, 2013, 123 (04) :176-182

[52] Effects of antioxidant supplementation on postprandial oxidative stress and endothelial dysfunction: A single-blind, 15-day clinical trial in patients with untreated type 2 diabetes, subjects with impaired glucose tolerance, and healthy controls [J].

Neri, S ;

Signorelli, SS ;

Torrisi, B ;

Pulvirenti, D ;

Mauceri, B ;

Abate, G ;

Ignaccolo, L ;

Bordonaro, F ;

Cilio, D ;

Calvagno, S ;

Leotta, C .

CLINICAL THERAPEUTICS, 2005, 27 (11) :1764-1773

[53] Role of oxidized low density lipoproteins and free fatty acids in the pathogenesis of glomerulopathy and tubulointerstitial lesions in type 2 diabetes [J].

Nosadini, R. ;

Tonolo, G. .

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2011, 21 (02) :79-85

[54] Increased levels of tumour necrosis factor-α (TNF-α) in patients with Type II diabetes mellitus after myocardial infarction are related to endothelial dysfunction [J].

Nystrom, Thomas ;

Nygren, Arne ;

Sjoholm, Ake .

CLINICAL SCIENCE, 2006, 110 (06) :673-681

[55] Differences in the inflammatory response between patients with and those without diabetes mellitus after coronary stenting [J].

Paiva, Maria Sanali M. ;

Serrano, Carlos V., Jr. ;

Nicolau, Jose Carlos ;

Jalbut, Bruna O. ;

Fernandes, Juliano L. ;

De Lemos, James A. ;

Blotta, Maria Heloisa S. L. ;

De Oliveira, Romulo T. D. ;

De Oliveira, Itamar R. ;

De Oliveira, Ludmilla Da A. R. R. ;

Ramires, Jose Antonio F. .

JOURNAL OF INTERVENTIONAL CARDIOLOGY, 2008, 21 (05) :403-409

[56] Assessment of the effects of the A3872G polymorphism on the C-reactive protein gene in patients with diabetes mellitus type 2 [J].

Papaoikonomou, Stavroula ;

Tousoulis, Dimitris ;

Tentolouris, Nikolaos ;

Papadogiannis, Dimitris ;

Miliou, Antigoni ;

Hatzis, George ;

Papageorgiou, Nikolaos ;

Siasos, Gerasimos ;

Tsioufis, Costas ;

Latsios, George ;

Stefanadis, Christodoulos .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2011, 151 (02) :243-245

[57] Interleukin-6 is an independent predictor of mortality in patients starting dialysis treatment [J].

Pecoits-Filho, R ;

Bárány, P ;

Lindholm, B ;

Heimbürger, O ;

Stenvinkel, P .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2002, 17 (09) :1684-1688

[58] Impact of rosiglitazone and glyburide on nitrosative stress and myocardial blood flow regulation in type 2 diabetes mellitus [J].

Pop-Busui, Rodica ;

Oral, Elif ;

Raffel, David ;

Byun, Jaeman ;

Bajirovic, Valida ;

Vivekanandan-Giri, Anuradha ;

Kellogg, Aaron ;

Pennathur, Subramaniam ;

Stevens, Martin J. .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2009, 58 (07) :989-994

[59] The Munich Myocardial Infarction Registry: impact of C-reactive protein and kidney function on hospital mortality in diabetic patients [J].

Schnell, Oliver ;

Braun, Karl Friedrich ;

Mueller, Martin ;

Standl, Eberhard ;

Otter, Wolfgang .

DIABETES & VASCULAR DISEASE RESEARCH, 2010, 7 (03) :225-230

[60] Aggressive antihypertensive therapy based on hydrochlorothiazide, candesartan or lisinopril as initial choice in hypertensive type II diabetic individuals: effects on albumin excretion, endothelial function and inflammation in a double-blind, randomized clinical trial [J].

Schram, MT ;

van Ittersum, FJ ;

Spoelstra-de Man, A ;

van Dijk, RAJM ;

Schalkwijk, CG ;

IJzerman, RG ;

Twisk, JWR ;

Stehouwer, CDA .

JOURNAL OF HUMAN HYPERTENSION, 2005, 19 (06) :429-437

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