Capsazepine partially inhibits neurally mediated gastric mucus secretion following activation of protease-activated receptor 2

被引：17
|
作者：
Kawabata, A [1 ]
Kinoshita, M [1 ]
Kuroda, R [1 ]
Kakehi, K [1 ]
机构：
[1] Kinki Univ, Fac Pharmaceut Sci, Higashiosaka, Osaka 5778502, Japan
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2002年 / 29卷 / 04期
关键词：
protease-activated receptor-2; vanilloid receptor 1;
D O I：
10.1046/j.1440-1681.2002.03641.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Protease-activated receptor 2 (PAR2), present in capsaicin-sensitive sensory neurons, induces gastric mucus secretion and mucosal cytoprotection. 2. We studied the possible cross-talk between PAR2 and vanilloid receptor 1 (VR1). The VR1 antagonist capsazepine partially inhibited the PAR2-mediated increase in gastric mucus secretion. 3. Thus, activation of VR1 is responsible, at least in part, for the neurally mediated mucosal cytoprotection following activation of PAR2.
引用
收藏
页码：360 / 361
页数：2
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