Synthesis of new carborane-based amino acids

被引：19

作者：

Stogniy, Marina Yu. ^{[1
]}

Zakharova, Maria V. ^{[1
]}

Sivaev, Igor B. ^{[1
]}

Godovikov, Ivan A. ^{[1
]}

Chizov, Alexander O. ^{[2
]}

Bregadze, Vladimir I. ^{[1
]}

机构：

[1] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow 119991, Russia

[2] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia

来源：

POLYHEDRON | 2013年 / 55卷

基金：

俄罗斯基础研究基金会;

关键词：

closo-Carborane; nido-Carborane; Amino acids; Synthesis; POLYHEDRAL BORON-COMPOUNDS; L-ORTHO-CARBORANYLALANINE; ENANTIOSELECTIVE SYNTHESIS; FUNCTIONAL-DERIVATIVES; OXONIUM DERIVATIVES; CHEMISTRY; CONVENIENT;

D O I：

10.1016/j.poly.2013.02.076

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of new boron-containing amino acids 1-HOOCCH(NH2)(CH2)(n)S-1,2-C2B10H11 (n = 4-6) was prepared by alkylation of 1-mercapto-ortho-carborane with omega-bromoalkylacetamido diethylmalonates followed by acid hydrolysis and decarboxylation. Mild deboronation of the c/oso-carborane cage with CsF gives cesium salts of the corresponding nido-carborane based amino acids Cs[7-HOOccH(NH2)(CH2)(n) S-7,8-C(2)B9H(l1)] d (n = 4-6). The compounds synthesized can be used in radionuclide diagnostics and boron neutron capture therapy of cancer(C) . 2013 Elsevier Ltd. All rights reserved.

引用

页码：117 / 120

页数：4

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