HEMOLYSIS ANALYSIS OF AXIAL BLOOD PUMPS WITH VARIOUS STRUCTURE IMPELLERS

被引：9

作者：

Chen, Zengsheng ^{[1
]}

Yao, Zhaohui ^{[1
]}

Zhu, Lailai ^{[1
]}

Zhang, Xiwen ^{[1
]}

机构：

[1] Tsinghua Univ, Sch Aerosp, Dept Engn Mech, Beijing 100084, Peoples R China

来源：

JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY | 2013年 / 13卷 / 04期

基金：

中国博士后科学基金; 美国国家科学基金会;

关键词：

Axial blood pump; impeller vane structure; hemolysis; FLUID-DYNAMICS MODEL; FLOW; DAMAGE; DIFFUSER;

D O I：

10.1142/S0219519413500541

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Low hemolysis is an important factor for axial blood pumps that has been used in patients with heart failure. The structure of impellers plays a key role in the hemolytic properties of axial blood pumps. Axial blood pumps with various structure impellers exhibit different hemolytic characteristic. In the present study, we aimed to investigate the type of impellers structures in axial blood pumps that contain the best low hemolytic properties. Also, it is expensive and time-consuming to validate the axial blood pump's hemolytic property by in vivo experiments. Therefore, in the present study, the numerical method was applied to analyze the hemolytic property in a blood pump. Specifically, the hemolysis of the pump was calculated by using a forward Euler approach based on the changes in shear stress and related exposure times along the particle trace lines. The different vane structures and rotational speed that affect hemolysis were analyzed and compared. The results showed that long-short alternant vanes exhibited the best hemolytic property which could be utilized in the optimization design of axial blood pumps.

引用

页数：15

共 41 条

[1]

ANSYS Inc, ANS CFX PROGR DOC

[2] Assessment of hemolysis related quantities in a microaxial blood pump by computational fluid dynamics [J].

Apel, J ;

Paul, R ;

Klaus, S ;

Siess, T ;

Reul, H .

ARTIFICIAL ORGANS, 2001, 25 (05) :341-347

[3] A validated computational fluid dynamics model to estimate hemolysis in a rotary blood pump [J].

Arvand, A ;

Hormes, M ;

Reul, H .

ARTIFICIAL ORGANS, 2005, 29 (07) :531-540

[4] 3-DIMENSIONAL NUMERICAL PREDICTION OF STRESS LOADING OF BLOOD PARTICLES IN A CENTRIFUGAL PUMP [J].

BLUDSZUWEIT, C .

ARTIFICIAL ORGANS, 1995, 19 (07) :590-596

[5]

Bludszuweit CA, 1994, THESIS U STRATHELYDE

[6]

Butler K C, 1992, ASAIO J, V38, pM296, DOI 10.1097/00002480-199207000-00041

[7] Experimental and numerical study on the hemodynamics of stenosed carotid bifurcation [J].

Cheung, Sherman C. P. ;

Wong, Kelvin K. L. ;

Yeoh, Guan Heng ;

Yang, William ;

Tu, Jiyuan ;

Beare, Richard ;

Thanh Phan .

AUSTRALASIAN PHYSICAL & ENGINEERING SCIENCES IN MEDICINE, 2010, 33 (04) :319-328

[8] Computational prediction of mechanical hemolysis in aortic valved prostheses [J].

de Tullio, M. D. ;

Nam, J. ;

Pascazio, G. ;

Balaras, E. ;

Verzicco, R. .

EUROPEAN JOURNAL OF MECHANICS B-FLUIDS, 2012, 35 :47-53

[9]

DeBakey ME, 1997, ARTIF ORGANS, V21, P1149

[10] The odyssey of the artificial heart [J].

DeBakey, ME .

ARTIFICIAL ORGANS, 2000, 24 (06) :405-411

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