Synthesis and reactions of 3-[3-(dimethylamino)propenoyl]-1,7-diphenyl[1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-one

被引：5

作者：

Farghaly, Thoraya A. ^{[1
]}

机构：

[1] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt

来源：

JOURNAL OF CHEMICAL RESEARCH | 2008年 / 03期

关键词：

enaminone; dimethyformamide dimethylacetal; triazolo[4,3-a] pyrimidin-5(1H)-one; pyridines;

D O I：

10.3184/030823408X303989

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

3-Acetyl-1,7-diphenyl[1,2,4]triazolo[4,3-a]pyrimidin-5(H)-one (1) reacts with N,N-dimethylformamide dimethylacetal (DMFDMA) yielding the enaminone 2. The latter compound reacts with active methylene compounds, hydrazine hydrate, hydroxylamine and some heterocyclic amines to afford trisubstituted pyridine, substituted pyrazole, substituted isoxazole and azolopyrimidines. The antimicrobial activities of the compounds prepared were screened.

引用

页码：152 / 156

页数：5

共 22 条

[21] Reactions of nitrilimines with heterocyclic amines and enamines. Convenient methodology for synthesis and annulation of heterocycles
Shawali, Ahmad S.
Edrees, Mastoura M.
[J]. ARKIVOC, 2006, : 292 - 365
[22] A facile one-pot regioselective synthesis of [1,2,4]triazolo[4,3-a]5(1H)-pyrimidinones via tandem Japp-Klingemann, smiles rearrangement, and cyclization reactions
Shawali, AS
Abdallah, MA
Mosselhi, MAN
Farghaly, TA
[J]. HETEROATOM CHEMISTRY, 2002, 13 (02) : 136 - 140

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