The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation

被引：46

作者：

Mahmoudi, Morteza ^{[1
,2
]}

Monopoli, Marco P. ^{[3
]}

Rezaei, Meisam ^{[1
]}

Lynch, Iseult ^{[3
]}

Bertoli, Filippo ^{[3
]}

McManus, Jennifer J. ^{[4
]}

Dawson, Kenneth A. ^{[3
]}

机构：

[1] Univ Tehran Med Sci, Dept Nanotechnol, Fac Pharm, Tehran 141556451, Iran

[2] Univ Tehran Med Sci, Nanotechnol Res Ctr, Fac Pharm, Tehran 141556451, Iran

[3] Univ Coll Dublin Belfield, Dept Chem & Chem Biol, Ctr BioNano Interact, Dublin 4, Ireland

[4] Natl Univ Ireland Maynooth, Dept Chem, Maynooth, Kildare, Ireland

来源：

CHEMBIOCHEM | 2013年 / 14卷 / 05期

基金：

爱尔兰科学基金会;

关键词：

fibrillation; inhibitory effect; nanomaterials; physicochemical properties; protein corona; IN-VITRO; NANOPARTICLES; AGGREGATION; INHIBITION; FIBRILS; FIBRILLOGENESIS; CURVATURE; TOXICITY; MODEL;

D O I：

10.1002/cbic.201300007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Put your coat on: It is well recognized that the surfaces of nanomaterials in biological media are covered by various biomolecules (e. g., proteins). A) The protein corona creates a shell over different nanomaterials, regardless of their physicochemical properties (e. g., composition and shape), resulting in reduced levels of amyloid beta fibril formation. B) Pristine nanomaterials might have acceleratory effects on the fibrillation of amyloid beta.

引用

页码：568 / 572

页数：5

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