Nagelamides X-Z, Dimeric Bromopyrrole Alkaloids from a Marine Sponge Agelas sp.

被引：41

作者：

Tanaka, Naonobu ^{[1
]}

Kusama, Taishi ^{[1
]}

Takahashi-Nakaguchi, Azusa ^{[2
]}

Gonoi, Tohru ^{[2
]}

Fromont, Jane ^{[3
]}

Kobayashi, Jun'ichi ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Chiba Univ, Mycol Res Ctr, Chiba 2608673, Japan

[3] Western Australian Museum, Welshpool Dc, WA 6986, Australia

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 13期

关键词：

PYRROLE-IMIDAZOLE ALKALOIDS; BENZOSCEPTRIN C; OROIDES;

D O I：

10.1021/ol401291n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new dimeric bromopyrrole alkaloids, nagelamides X-Z (1-3), were isolated from a marine sponge Agelas sp. Nagelamides X (1) and Y (2) possess a novel tricyclic skeleton consisting of spiro-bonded tetrahydrobenzaminoimidazole and aminoimidazolidine moieties. Nagelamide Z (3) is the first dimeric bromopyrrole alkaloid involving the C-8 position in dimerization. The structures of 1-3 were elucidated on the basis of spectroscopic data. Nagelamides X-Z (1-3) exhibited antimicrobial activity.

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收藏

页码：3262 / 3265

页数：4

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