These lectures take a look at how observations with adaptive optics (AO) are beginning to influence our understanding of active galactic nuclei (AGN). By focussing on a few specific topics, the aim is to highlight the different ways in which enhanced spatial resolution from AO can aid the scientific analysis of AGN data. After presenting some background about how AO works, I will describe a few recent observations made with AO of QSO host galaxies, the Galactic Center, and nearby AGN, and show how they have contributed to our knowledge of these enigmatic objects. (C) 2008 Elsevier B.V. All rights reserved.