Cannabisol, a novel Δ9-THC dimer possessing a unique methylene bridge, isolated from Cannabis sativa

被引：25

作者：

Zulfiqar, Fazila ^{[1
]}

Ross, Samir A. ^{[1
,2
]}

Slade, Desmond ^{[1
]}

Ahmed, Safwat A. ^{[1
]}

Radwan, Mohamed M. ^{[1
]}

Ali, Zulfiqar ^{[1
]}

Khan, Ikhlas A. ^{[1
,2
]}

ElSohly, Mahmoud A. ^{[1
,3
]}

机构：

[1] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Dept Pharmaceut, University, MS 38677 USA

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 28期

基金：

美国国家卫生研究院;

关键词：

Cannabis sativa; Cannabisol; C-bridged dimer; CONSTITUENTS; MARIJUANA;

D O I：

10.1016/j.tetlet.2012.04.139

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cannabisol (1), a unique dimer of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) with a methylene bridge, was isolated from Cannabis sativa. This is the first example of a C-bridged dimeric cannabinoid. The structure of 1 was unambiguously deduced by HRESIMS. GCMS, and NMR spectroscopy. A plausible biogenesis of 1 is described. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：3560 / 3562

页数：3

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