The Prognostic Value of Tumor-Infiltrating Neutrophils in Gastric Adenocarcinoma after Resection

被引:97
作者
Zhao, Jing-jing [1 ,2 ]
Pan, Ke [1 ,2 ]
Wang, Wei [1 ,2 ,3 ]
Chen, Ju-gao [1 ,2 ]
Wu, Yan-heng [5 ]
Lv, Lin [1 ,2 ]
Li, Jian-jun [1 ,2 ]
Chen, Yi-bing [1 ,2 ]
Wang, Dan-dan [1 ,2 ]
Pan, Qiu-zhong [1 ,2 ]
Li, Xiao-dong [1 ,2 ,4 ]
Xia, Jian-chuan [1 ,2 ]
机构
[1] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol So China, Guangzhou 510275, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Ctr Canc, Dept Expt Res, Guangzhou 510275, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Ctr Canc, Dept Gastr & Pancreat Surg, Guangzhou 510275, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Ctr Canc, Dept Thorac Oncol, Guangzhou 510275, Guangdong, Peoples R China
[5] Jinan Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
PREDICTS POOR SURVIVAL; PREOPERATIVE NEUTROPHIL; ANGIOGENIC SWITCH; MOUSE MODEL; CANCER; CELLS; CARCINOGENESIS; CARCINOMA; RATIO; INFLAMMATION;
D O I
10.1371/journal.pone.0033655
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Several pieces of evidence indicate that tumor-infiltrating neutrophils (TINs) are correlated to tumor progression. In the current study, we explore the relationship between TINs and clinicopathological features of gastric adenocarcinoma patients. Furthermore, we investigated the prognostic value of TINs. Patients and Methods: The study was comprised of two groups, training group (115 patients) and test group (97 patients). Biomarkers (intratumoral CD15+ neutrophils) were assessed by immunohistochemistry. The relationship between clinicopathological features and patient outcome were evaluated using Cox regression and Kaplan-Meier analysis. Results: Immunohistochemical detection showed that the tumor-infiltrating neutrophils (TINs) in the training group ranged from 0.00-115.70 cells/high-power microscopic field (HPF) and the median number was 21.60 cells/HPF. Based on the median number, the patients were divided into high and low TINs groups. Chi-square test analysis revealed that the density of CD15+ TINs was positively associated with lymph node metastasis (p = 0.024), distance metastasis (p = 0.004) and UICC (International Union Against Cancer) staging (p = 0.028). Kaplan-Meier analysis showed that patients with a lower density of TINs had a better prognosis than patients with a higher density of TINs (p = 0.002). Multivariate Cox's analysis showed that the density of CD15+ TINs was an independent prognostic factor for overall survival of gastric adenocarcinoma patients. Using another 97 patients as a test group and basing on the median number of TINs (21.60 cells/HPF) coming from the training group, Kaplan-Meier analysis also showed that patients with a lower density of TINs had a better prognosis than patients with a higher density of TINs (p = 0.032). The results verify that the number of CD15+ TINs can predict the survival of gastric adenocarcinoma surgical patients. Conclusions: The presence of CD15+ TINs is an independent and unfavorable factor in the prognosis of gastric adenocarcinoma patients. Targeting CD15+ TINs may be a potential intervenient therapy in the future.
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页数:6
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