Brain Perfusion Assessment by Optical Contrast Tracking Using Time-Resolved Fluorescence Detection

被引：0
作者：
Milej, D. [1 ]
Gerega, A. [1 ]
Zolek, N. [1 ]
Kacprzak, M. [1 ]
Weigl, Wojciech [2 ]
Mayzner-Zawadzka, Ewa [2 ]
Maniewski, Roman [1 ]
Liebert, Adam [1 ]
机构：
[1] Polish Acad Sci, Nalecz Inst Biocybernet & Biomed Engn, Ks Trojdena 4, Warsaw, Poland
[2] Med Univ Warsaw, Dept Anesthesiol & Intensive Care, Warsaw, Poland
来源：
5TH EUROPEAN CONFERENCE OF THE INTERNATIONAL FEDERATION FOR MEDICAL AND BIOLOGICAL ENGINEERING, PTS 1 AND 2 | 2012年 / 37卷
关键词：
reflectance; fluorescence; time-resolved; Indocyanine green (ICG); brain imaging; NEAR-INFRARED SPECTROSCOPY; CEREBRAL-BLOOD-FLOW; INDOCYANINE GREEN;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this paper we present methodological studies on construction and application of optical brain monitoring system utilizing time-resolved detection of fluorescence excited in the dye circulating in the human brain. Series of Monte Carlo simulations and time-resolved measurements of diffuse reflectance and fluorescence were carried out. Measurements on physical phantoms allowing for assessment of dynamic inflow of Indocyanine Green (ICG) were performed. Finally, in-vivo measurements on the healthy subjects as well as patients with brain perfusion insufficiencies were carried out during intravenous administration of ICG. Obtained results show good signal-to-noise ratio for fluorescence signals. The simulations and phantom experiments allowed to optimize conditions of the measurement - dose of the dye injected and source-detector separation used in the in-vivo experiments. Preliminary analysis of signals obtained during in-vivo measurements in patients show that the fluorescence measurements can be used to assess brain perfusion insufficiencies.
引用
收藏
页码：374 / 376
页数：3
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