Human protein C concentrates in adult septic patients

被引：5

作者：

Landoni, Giovanni ^{[1
]}

Crivellari, Martina ^{[1
]}

Monti, Giacomo ^{[1
]}

Gerli, Chiara ^{[1
]}

Silvani, Paolo ^{[1
]}

Zangrillo, Alberto ^{[1
]}

机构：

[1] Ist Sci San Raffaele, Dept Cardiothorac Anesthesia & Intens Care, I-20132 Milan, Italy

来源：

SIGNA VITAE | 2008年 / 3卷 / 02期

关键词：

sepsis; protein C; cardiac surgery;

D O I：

10.22514/SV32.102008.1

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Some case reports and case series suggest that protein C concentrates may improve the outcome in patients with congenital or acquired protein C deficiency (not only in those with sepsis induced purpura fulminans). We reviewed the published literature on the use of protein C concentrates in adult septic patients and found that it is limited to less than 70 patients reported in observational studies with a 70% survival, and added our personal experience (two adult patients with sepsis and contraindications to recombinant activated protein C).

引用

页码：13 / 17

页数：5

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