Competitive study of monoclonal antibodies against the HIV-1 Gp41 core structure

被引：1

作者：

Usami, O

Xiao, P

Ling, H

Hattori, T

机构：

[1] Tohoku Univ, Grad Sch Med, Div Infect & Resp Dis, Aoba Ku, Sendai, Miyagi 9808574, Japan

[2] Harbin Med Coll, Dept Microbiol & Parasitol, Harbin 150086, Peoples R China

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2006年 / 50卷 / 02期

关键词：

HIV-1; Gp41; 50.69; antibody; 98.6;

D O I：

10.1111/j.1348-0421.2006.tb03778.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Monoclonal antibodies (MAbs) 50.69, 98.6, and T26 bind specifically to the core structure of the human immunodeficiency virus type 1 (HIV-1) envelope transmembrane glycoprotein (gp41). To clarify the specificity of the anti-core structure MAbs, we performed competitive assays using the MAbs to the H9 human T cell line infected with the IIIB strain of HIV-1 (H9/IIIB). Bound MAb 50.69 inhibited MAb 98.6 binding unidirectionally. The reason for the unidirectional cross competition between MAbs 50.69 and 98.6 is not clear, but these results help to define the antigenic structure of gp41 on the surface of infected cells.

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页码：131 / 134

页数：4

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