The role of the leukemia inhibitory factor receptor in neuroprotective signaling

被引：37

作者：

Davis, Stephanie M.

Pennypacker, Keith R. ^{[1
,2
]}

机构：

[1] Univ Kentucky, Dept Neurol, Ctr Adv Translat Stroke Sci, Bldg BBSRB,Off B457, Lexington, KY 40536 USA

[2] Univ Kentucky, Dept Neurosci, Ctr Adv Translat Stroke Sci, Bldg BBSRB,Off B457, Lexington, KY 40536 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 2018年 / 183卷

关键词：

Cytokine; Signal transduction; Brain injury; Inflammation; CILIARY NEUROTROPHIC FACTOR; NEURAL STEM-CELLS; LIMITS AUTOIMMUNE DEMYELINATION; OLIGODENDROCYTE PRECURSOR CELLS; AMYOTROPHIC-LATERAL-SCLEROSIS; FIBROBLAST GROWTH FACTOR-2; ADULT CNS NEUROGENESIS; CENTRAL-NERVOUS-SYSTEM; ISCHEMIC BRAIN-INJURY; REGULATORY T-CELLS;

D O I：

10.1016/j.pharmthera.2017.08.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce intracellular signaling in neurons and oligoden-drocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.

引用

页码：50 / 57

页数：8

共 50 条

[31] Leukemia inhibitory factor restores the hypertrophic response to increased loading in the LIF(-/-) mouse [J].

Spangenburg, Espen E. ;

Booth, Frank W. .

CYTOKINE, 2006, 34 (3-4) :125-130

[32] A Unique Loop Structure in Oncostatin M Determines Binding Affinity toward Oncostatin M Receptor and Leukemia Inhibitory Factor Receptor [J].

Chollangi, Srinivas ;

Mather, Timothy ;

Rodgers, Karla K. ;

Ash, John D. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (39) :32848-32859

[33] Effects of leptin and leukemia inhibitory factor on preimplantation development and STAT3 signaling of mouse embryos in vitro [J].

Fedorcsák, P ;

Storeng, R .

BIOLOGY OF REPRODUCTION, 2003, 69 (05) :1531-1538

[34] Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor [J].

März, P ;

Özbek, S ;

Fischer, M ;

Voltz, N ;

Otten, U ;

Rose-John, S .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2002, 269 (12) :3023-3031

[35] The role of platelet-derived growth factor receptor in eotaxin signaling of eosinophils [J].

Adachi, T ;

Hanaka, S ;

Yano, T ;

Yamamura, K ;

Yoshihara, H ;

Nagase, H ;

Chihara, J ;

Ohta, K .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2006, 140 :28-34

[36] Evidence for a role of macrophage migration inhibitory factor in vascular disease [J].

Chen, ZP ;

Sakuma, M ;

Zago, AC ;

Zhang, XB ;

Shi, C ;

Leng, L ;

Mizue, Y ;

Bucala, R ;

Simon, DI .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (04) :709-714

[37] The role of macrophage migration inhibitory factor on glucose metabolism and diabetes [J].

C. Toso ;

J. A. Emamaullee ;

S. Merani ;

A. M. J. Shapiro .

Diabetologia, 2008, 51 :1937-1946

[38] The role of macrophage migration inhibitory factor on glucose metabolism and diabetes [J].

Toso, C. ;

Emamaullee, J. A. ;

Merani, S. ;

Shapiro, A. M. J. .

DIABETOLOGIA, 2008, 51 (11) :1937-1946

[39] DIFFERENCES IN NUCLEAR SIGNALING BY LEUKEMIA INHIBITORY FACTOR AND INTERFERON-GAMMA - THE ROLE OF STAT PROTEINS IN REGULATING VASOACTIVE-INTESTINAL-PEPTIDE GENE-EXPRESSION [J].

SYMES, AJ ;

CORPUS, L ;

FINK, JS .

JOURNAL OF NEUROCHEMISTRY, 1995, 65 (05) :1926-1933

[40] Potential neuroprotective role of transforming growth factor β1 (TGFβ1) in the brain [J].

Martinez-Canabal, Alonso .

INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2015, 125 (01) :1-9

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