The role of the leukemia inhibitory factor receptor in neuroprotective signaling

被引：31
作者：
Davis, Stephanie M.
Pennypacker, Keith R. [1 ,2 ]
机构：
[1] Univ Kentucky, Dept Neurol, Ctr Adv Translat Stroke Sci, Bldg BBSRB,Off B457, Lexington, KY 40536 USA
[2] Univ Kentucky, Dept Neurosci, Ctr Adv Translat Stroke Sci, Bldg BBSRB,Off B457, Lexington, KY 40536 USA
来源：
PHARMACOLOGY & THERAPEUTICS | 2018年 / 183卷
关键词：
Cytokine; Signal transduction; Brain injury; Inflammation; CILIARY NEUROTROPHIC FACTOR; NEURAL STEM-CELLS; LIMITS AUTOIMMUNE DEMYELINATION; OLIGODENDROCYTE PRECURSOR CELLS; AMYOTROPHIC-LATERAL-SCLEROSIS; FIBROBLAST GROWTH FACTOR-2; ADULT CNS NEUROGENESIS; CENTRAL-NERVOUS-SYSTEM; ISCHEMIC BRAIN-INJURY; REGULATORY T-CELLS;
D O I：
10.1016/j.pharmthera.2017.08.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce intracellular signaling in neurons and oligoden-drocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.
引用
收藏
页码：50 / 57
页数：8
相关论文
共 50 条
  • [1] The Role of Leukemia Inhibitory Factor Receptor Signaling in Skeletal Muscle Growth, Injury and Disease
    Hunt, Liam C.
    White, Jason
    GROWTH FACTORS AND CYTOKINES IN SKELETAL MUSCLE DEVELOPMENT, GROWTH, REGENERATION AND DISEASE, 2016, 900 : 45 - 59
  • [2] An anti-inflammatory role for leukemia inhibitory factor receptor signaling in regenerating skeletal muscle
    Liam C. Hunt
    Aradhana Upadhyay
    Jalal A. Jazayeri
    Elizabeth M. Tudor
    Jason D. White
    Histochemistry and Cell Biology, 2013, 139 : 13 - 34
  • [3] An anti-inflammatory role for leukemia inhibitory factor receptor signaling in regenerating skeletal muscle
    Hunt, Liam C.
    Upadhyay, Aradhana
    Jazayeri, Jalal A.
    Tudor, Elizabeth M.
    White, Jason D.
    HISTOCHEMISTRY AND CELL BIOLOGY, 2013, 139 (01) : 13 - 34
  • [4] Analysis of leukemia inhibitory factor and leukemia inhibitory factor receptor in embryonic and adult zebrafish (Danio rerio)
    Hanington, Patrick C.
    Patten, Shunmoogum A.
    Reaume, Laura M.
    Waskiewicz, Andrew J.
    Belosevic, Miodrag
    Ali, Declan W.
    DEVELOPMENTAL BIOLOGY, 2008, 314 (02) : 250 - 260
  • [5] Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination
    Emery, Ben
    Cate, Holly S.
    Marriottt, Mark
    Merson, Tobias
    Binder, Michele D.
    Snell, Cameron
    Soo, Pik Ying
    Murray, Simon
    Croker, Ben
    Zhang, Jian-Guo
    Alexander, Warren S.
    Cooper, Helen
    Butzkueven, Helmut
    Kilpatrick, Trevor J.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (20) : 7859 - 7864
  • [6] The emerging role of leukemia inhibitory factor in cancer and therapy
    Zhang, Cen
    Liu, Juan
    Wang, Jianming
    Hu, Wenwei
    Feng, Zhaohui
    PHARMACOLOGY & THERAPEUTICS, 2021, 221
  • [7] The role of leukemia inhibitory factor in tubal ectopic pregnancy
    Krishnan, T.
    Winship, A.
    Sonderegger, S.
    Menkhorst, E.
    Horne, A. W.
    Brown, J.
    Zhang, J. -G.
    Nicola, N. A.
    Tong, S.
    Dimitriadis, E.
    PLACENTA, 2013, 34 (11) : 1014 - 1019
  • [8] Expression of leukemia inhibitory factor and its receptor in preimplantation embryos
    Chen, HF
    Shew, JY
    Ho, HN
    Hsu, WL
    Yang, YS
    FERTILITY AND STERILITY, 1999, 72 (04) : 713 - 719
  • [9] Characterization of the leukemia inhibitory factor receptor in the goldfish (Carassius auratus)
    Hanington, PC
    Belosevic, M
    FISH & SHELLFISH IMMUNOLOGY, 2005, 18 (05) : 359 - 369
  • [10] NEUROPROTECTIVE EFFECT OF CHOLINERGIC DIFFERENTIATION FACTOR LEUKEMIA INHIBITORY FACTOR ON WOBBLER MURINE MOTOR-NEURON DISEASE
    IKEDA, K
    IWASAKI, Y
    TAGAYA, N
    SHIOJIMA, T
    KINOSHITA, M
    MUSCLE & NERVE, 1995, 18 (11) : 1344 - 1347
12345