Therapeutic potential of quercetin for the prevention of various drug and chemical-induced nephrotoxicity: A review

Quercetin is a flavonoid and has been reported to have a wide range of pharmacological properties. The possible mechanisms involved in the nephroprotective activity of quercetin were discussed in this review. Quercetin exhibited nephroprotective activity against valproic acid, cisplatin, doxorubicin, streptozotocin, sodium fluoride, methotrexate, lead acetate, cadmium, lindane, adenine, paracetamol, gallium arsenide, chlorpyrifos, TiO2, ferric nitrile triacetate, dichlorvas, melphalan, HgCl2, ischaemic reperfusion, gentamicin, snake venom, ammonium fluoride, arsenate, atrazine, Ionising radiation and iron in various animal models due to its antioxidant, free radical-scavenging, anti-inflammatory, anti-apoptotic mechanisms. In this review, we provide an overview of the possible mechanisms by which quercetin reduced the nephrotoxicity-induced by different nephrotoxicants. This will help the scientific community to reduce the nephrotoxicity using quercetin.