Therapeutic potential of quercetin for the prevention of various drug and chemical-induced nephrotoxicity: A review

被引：4

作者：

Kilaru, Naveen Babu ^{[1
]}

Pingili, Ravindra Babu ^{[2
]}

Dirisala, Vijaya R. ^{[3
]}

Saka, Vara Prasad ^{[4
]}

Kodali, Tanvija ^{[5
]}

Toleti, Vyshnavi ^{[5
]}

Koppula, Sirisha ^{[5
]}

机构：

[1] KVSR Siddhartha Coll Pharmaceut Sci, Dept Pharmaceut & Biotechnol, Vijayawada 520010, Andhra Pradesh, India

[2] SVKMs NMIMS Deemed Univ, Sch Pharm & Technol Management, Dept Pharmacol, Shirpur 425405, Maharashtra, India

[3] Vignans Fdn Sci Technol & Res Deemed Univ, Dept Biotechnol, Guntur 522213, Andhra Pradesh, India

[4] Cent Council Res Homoeopathy, Dr Anjali Chatarji Reg Res Inst Homoeopathy, DS Pharmacol, Kolkata 700106, W Bengal, India

[5] KVSR Siddhartha Coll Pharmaceut Sci, Dept Pharm Practice, Vijayawada 520010, Andhra Pradesh, India

来源：

ANNALS OF PHYTOMEDICINE-AN INTERNATIONAL JOURNAL | 2022年 / 11卷 / 02期

关键词：

Quercetin; Antioxidant; Nephroprotective; Nephrotoxicity; Toxicology; INDUCED OXIDATIVE STRESS; RENAL INJURY; KIDNEY; RATS; LIVER; GENTAMICIN; APOPTOSIS; TOXICITY; DAMAGE;

D O I：

10.54085/ap.2022.11.2.5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Quercetin is a flavonoid and has been reported to have a wide range of pharmacological properties. The possible mechanisms involved in the nephroprotective activity of quercetin were discussed in this review. Quercetin exhibited nephroprotective activity against valproic acid, cisplatin, doxorubicin, streptozotocin, sodium fluoride, methotrexate, lead acetate, cadmium, lindane, adenine, paracetamol, gallium arsenide, chlorpyrifos, TiO2, ferric nitrile triacetate, dichlorvas, melphalan, HgCl2, ischaemic reperfusion, gentamicin, snake venom, ammonium fluoride, arsenate, atrazine, Ionising radiation and iron in various animal models due to its antioxidant, free radical-scavenging, anti-inflammatory, anti-apoptotic mechanisms. In this review, we provide an overview of the possible mechanisms by which quercetin reduced the nephrotoxicity-induced by different nephrotoxicants. This will help the scientific community to reduce the nephrotoxicity using quercetin.

引用

页码：42 / 51

页数：10

共 39 条

[1]

Abarikwu Sunny O, 2014, Toxicol Int, V21, P148, DOI 10.4103/0971-6580.139794

[2] Protective Effect of Quercetin against Gentamicin-Induced Nephrotoxicity in Rats [J].