IgA synthesis: a form of functional immune adaptation extending beyond gut

被引：58

作者：

Sutherland, Duncan B. ^{[1
]}

Fagarasan, Sidonia ^{[1
]}

机构：

[1] RIKEN Yokohama, Res Ctr Allergy & Immunol, Lab Mucosal Immun, Yokohama, Kanagawa 2300045, Japan

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 03期

关键词：

SEGMENTED FILAMENTOUS BACTERIA; FOLLICULAR DENDRITIC CELLS; REGULATORY T-CELLS; IMMUNOGLOBULIN-A GENERATION; INTESTINAL LYMPHOID-TISSUE; CLASS-SWITCH RECOMBINATION; LIVED PLASMA-CELLS; GERMINAL CENTER B; LAMINA PROPRIA; SECRETORY ANTIBODIES;

D O I：

10.1016/j.coi.2012.03.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunoglobulin A (IgA) is the most abundantly produced antibody isotype in mammals. The primary function of IgA is to maintain homeostasis at mucosal surfaces. IgA is generated in specialized gut associated lymphoid tissues (GALT) by T cell-dependent and T cell-independent mechanisms. Studies in mice have demonstrated that IgA diversification has an essential role in the regulation of gut microbiota. Aberrant bacterial growth, by activating innate and adaptive immune cells, has emerged as a risk factor for inflammatory diseases such as metabolic disorders and autoimmune diseases. Dynamic diversification of IgA shields bacterial antigens preventing inflammatory responses, but when IgA regulation is suboptimal aberrant bacterial growth and inflammation can ensue.

引用

页码：261 / 268

页数：8

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