In Vitro Activities of 21 Antimicrobial Agents Alone and in Combination with Aminoglycosides or Fluoroquinolones against Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolates Causing Bacteremia

被引：18
|
作者：
Cha, Min Kyeong [1 ]
Kang, Cheol-In [2 ]
Kim, So Hyun [1 ,2 ]
Cho, Sun Young [2 ]
Ha, Young Eun [2 ]
Wi, Yu Mi [3 ]
Chung, Doo Ryeon [1 ,2 ]
Peck, Kyong Ran [2 ]
Song, Jae-Hoon [1 ,2 ]
机构：
[1] APFID, Seoul, South Korea
[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Infect Dis, Seoul, South Korea
[3] Sungkyunkwan Univ, Sch Med, Samsung Changwon Hosp, Div Infect Dis, Chang Won, South Korea
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
ANTIBIOTIC-THERAPY; MOLECULAR EPIDEMIOLOGY; SEPTIC SHOCK; RISK-FACTORS; INFECTIONS; SEPSIS; MONOTHERAPY; IMPACT;
D O I：
10.1128/AAC.01121-15
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We evaluated the in vitro activity of various antimicrobials alone and in combination against 291 extended-spectrum-beta-lactamase-producing Escherichia coli (ESBL-EC) isolates causing bacteremia in South Korean hospitals. Ceftazidime, cefepime, and piperacillin-tazobactam in combination with amikacin showed greater activity than found in combination with ciprofloxacin. In settings with a high prevalence of ESBL-producing pathogens, combination aminoglycoside antimicrobial therapy, especially with amikacin, may be considered for empirical therapy against suspected Gram-negative sepsis as a carbapenem-saving strategy.
引用
收藏
页码：5834 / 5837
页数：4
相关论文
共 50 条
  • [41] Occurrence of risk factors and antimicrobial resistance due to genes encoding extended-spectrum -lactamase (ESBL) - and/or AmpC -lactamase-producing Escherichia coli isolated from the hospitalised patients
    Koren, Jan
    Hrabovsky, Vladimir
    Kmetova, Marta
    Siegfried, Leonard
    Roderova, Magdalena
    Luha, Jan
    Liptakova, Adriana
    BIOLOGIA, 2019, 74 (03) : 325 - 333
  • [42] In Vitro Activity of Ceftaroline Alone and in Combination against Clinical Isolates of Resistant Gram-Negative Pathogens, Including β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa
    Vidaillac, Celine
    Leonard, Steve N.
    Sader, Helio S.
    Jones, Ronald N.
    Rybak, Michael J.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (06) : 2360 - 2366
  • [43] Pharmacodynamics of Piperacillin-Tazobactam/Amikacin Combination versus Meropenem against Extended-Spectrum β-Lactamase-Producing Escherichia coli in a Hollow Fiber Infection Model
    Islam, Kamrul
    Sime, Fekade B.
    Wallis, Steven C.
    Bauer, Michelle J.
    Naicker, Saiyuri
    Won, Hayoung
    Zowawi, Hosam M.
    Abu Choudhury, Md
    Shirin, Tahmina
    Habib, Zakir H.
    Harris, Patrick N. A.
    Flora, Meerjady S.
    Roberts, Jason A.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2022, 66 (09)
  • [44] Resistant mutant prevention concentration of fluoroquinolones in clinical isolates of extended spectrum beta-lactamase (ESBL) producing and non-producing strains of Escherichia coli
    Noguera, O.
    Rodriguez, J. C.
    Lopez, J. M.
    Ruiz, M.
    Royo, G.
    REVISTA ESPANOLA DE QUIMIOTERAPIA, 2009, 22 (01) : 30 - 33
  • [45] Risk Factors for Extended-Spectrum-β-Lactamase-Producing Escherichia coli in Community-Onset Bloodstream Infection: Impact on Long-Term Care Hospitals in Korea
    Baek, Yae Jee
    Kim, Young Ah
    Kim, Dokyun
    Shin, Jong Hee
    Uh, Young
    Shin, Kyeong Seob
    Shin, Jeong Hwan
    Jeong, Seok Hoon
    Lee, Geun Woo
    Lee, Eun Ji
    Kim, Dong-Sook
    Park, Yoon Soo
    ANNALS OF LABORATORY MEDICINE, 2021, 41 (05) : 455 - 462
  • [46] Impact of appropriateness of empiric therapy on outcomes in community-onset bacteremia by extended-spectrum-β-lactamase producing Escherichia coli and Klebisella pneumoniae definitively treated with carbapenems
    Joo, E-J.
    Park, D. A.
    Lee, N. R.
    Moon, S-y.
    Choi, J-K.
    Ko, J-H.
    Peck, K. R.
    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2017, 36 (11) : 2093 - 2100
  • [47] Emergence of Extended-Spectrum β-Lactamase-Producing Escherichia coli as a Cause of Community-Onset Bacteremia in South Korea: Risk Factors and Clinical Outcomes
    Park, Sun Hee
    Choi, Su-Mi
    Lee, Dong-Gun
    Kim, Jayoung
    Choi, Jung-Hyun
    Kim, Si-Hyun
    Kwon, Jae-Cheol
    Yoo, Jin-Hong
    MICROBIAL DRUG RESISTANCE, 2011, 17 (04) : 537 - 544
  • [48] Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella spp. in Community-Acquired Urinary Tract Infections and Their Antimicrobial Resistance
    Senol, Arzu
    Yakupogullari, Yusuf
    Senol, Feray Ferda
    KLIMIK JOURNAL, 2020, 33 (02) : 163 - 168
  • [49] Pharmacodynamic evaluation of piperacillin/tazobactam versus meropenem against extended-spectrum β-lactamase-producing and non-producing Escherichia coli clinical isolates in a hollow-fibre infection model
    Islam, Kamrul
    Sime, Fekade B.
    Wallis, Steven C.
    Bauer, Michelle J.
    Forde, Brian M.
    Harris, Patrick
    Shirin, Tahmina
    Habib, Zakir H.
    Flora, Meerjady S.
    Roberts, Jason A.
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2022, 77 (09) : 2448 - 2455
  • [50] Comparison of Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolates from Drinking Well Water and Pit Latrine Wastewater in a Rural Area of China
    Zhang, Hongna
    Gao, Yanxia
    Chang, Weishan
    BIOMED RESEARCH INTERNATIONAL, 2016, 2016
12345