Serum and peritoneal CA-125 levels as diagnostic test for endometriosis

被引:21
作者
Colacurci, N
Fortunato, N
DeFranciscis, P
Fratta, M
Cioffi, M
Zarcone, R
Cardone, A
机构
[1] UNIV NAPLES 2,SCH MED,INST GYNECOL & OBSTET,DEPT OBSTET & GYNECOL 2,NAPLES,ITALY
[2] UNIV NAPLES 2,SCH MED,INST GEN PATHOL & ONCOL,NAPLES,ITALY
来源
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 1996年 / 66卷 / 01期
关键词
CA-125; endometriosis; infertility; laparoscopy; peritoneal fluid; immunoradiometric assay;
D O I
10.1016/0301-2115(95)02372-0
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To evaluate the clinical utility of CA-125 in the diagnosis of endometriosis and to compare the sensitivity of the serum and the peritoneal test as indicator of disease. Study design: Peritoneal fluid was obtained at laparoscopy. The quantitative determination of CA-125 in serum and in peritoneal fluid was performed by IRMA-mat CA-125 'two-step method', a two-site immunoradiometric assay, using 35 and 60 U/ml as cutoff. Setting: Second Department of Gynecology and Obstetrics, Second University of Naples, Italy. Participants: A total of 26 women infertile undergoing diagnostic laparoscopy that exhibited endometriosis in 14 patients, normal pelvis in 12 patients (control group). Interventions: None. Results: CA-125 levels in peritoneal fluid were higher than those found in serum and were significantly elevated (P < 0.05), when compared with the control group, both in women with endometriosis stage I-II and stage III-IV. In serum, CA-125 levels increased only in advanced stage of endometriosis. Conclusions: Levels of CA-125 in peritoneal fluid seem to be a more sensitive indicator of disease than serum levels (0.86 vs. 0.36), especially in early stage endometriosis (0.80 vs. 0.20) which tends to be overlooked by the CA-125 serum test.
引用
收藏
页码:41 / 43
页数:3
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