Childhood growth hormone deficiency, a diagnosis in evolution: The intersection of growth hormone history and ethics

被引：5

作者：

Henry, Rohan K. ^{[1
]}

机构：

[1] Ohio State Univ, Dept Pediat, Sect Endocrinol, Nationwide Childrens Hosp,Coll Med, Columbus, OH 43205 USA

来源：

GROWTH HORMONE & IGF RESEARCH | 2020年 / 55卷

关键词：

Growth hormone deficiency (GHD); Growth hormone stimulation test; Human growth hormone; PROVOCATIVE TESTS; SHORT STATURE; CHILDREN; SECRETION; STANDARDIZATION; PREVALENCE; AUXOLOGY; THERAPY; PROGRAM; SAFETY;

D O I：

10.1016/j.ghir.2020.101358

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In 1958 the first recorded case of a patient treated with human growth hormone for growth hormone deficiency was published. Since that time, the source and availability of human growth hormone have changed. With the increased availability of growth hormone, there has been an uptrend in the level below which childhood growth hormone deficiency is diagnosed based on provocative GH stimulation testing. This increase is despite better specificity of growth hormone assays in addition to a lack of supportive evidence regarding appropriate normal values. With these trends the diagnosis of childhood growth hormone deficiency is evolving, and clinicians should be aware that this may have potential ethical implications.

引用

页数：4

共 44 条

[1] Growth Hormone Post-Marketing Surveillance: Safety, Sales, and the Unfinished Task Ahead [J].