A Low-Cost, Normally Closed, Solenoid Valve for Non-Contact Dispensing in the Sub-μL Range

We present a disposable, normally closed, non-contact dispensing valve for the sub-mu L range. The miniaturized solenoid valve (diameter: 8 mm, height: 27.25 mm) is compatible to standard Luer-Lock interfaces. A highly dynamic actuation principle enables opening times down to 1 ms. The dispensing performance was evaluated for water (eta = 1.03 mPas) and a 66% (w/w) glycerol/water solution (eta = 16.98 mPas), at pressures varying from 200 to 800 mbar. The experimentally determined minimal dispensing volume was 163 nL (CV 1.6%) for water and 123 nL (CV 4.5%) for 66% (w/w) glycerol/water. The low-cost polymer valve enables high precision dispensing of liquid volumes down to the lower end of the sub-mu L range comparable to high-end non-disposable micro-dispensing valves.