Metabolic Control Improves Long-Term Renal Allograft and Patient Survival in Type 1 Diabetes

被引:107
|
作者
Morath, Christian [1 ]
Zeier, Martin [1 ]
Doehler, Bernd [2 ]
Schmidt, Jan [3 ]
Nawroth, Peter P. [4 ]
Opelz, Gerhard [2 ]
机构
[1] Univ Heidelberg, Dept Nephrol, D-69120 Heidelberg, Germany
[2] Univ Heidelberg, Dept Transplantat Immunol, D-69120 Heidelberg, Germany
[3] Univ Heidelberg, Dept Transplantat Surg, D-69120 Heidelberg, Germany
[4] Univ Heidelberg, Dept Endocrinol, D-69120 Heidelberg, Germany
来源
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2008年 / 19卷 / 08期
关键词
D O I
10.1681/ASN.2007070804
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
It is a matter of debate whether pancreas allografts independently contribute to renal allograft and patient survival in individuals who have type 1 diabetes and receive a simultaneous pancreas and kidney transplant (SPK). Using data from the Collaborative Transplant Study, we studied patients who had type 1 diabetes and were recipients of deceased-donor kidneys (DDK), living-donor kidneys (LDK), or SPK. We analyzed graft and patient survival rates with a maximum of 18 yr of follow-up. DDK recipients had inferior graft and patient survival compared with LDK and SPK recipients. LDK recipients had superior graft and patient survival rates initially, but SPK recipients demonstrated equal survival rates toward the end of follow-up. Multivariate analysis, adjusting for pretransplantation cardiovascular risk, showed that patient survival of SPK recipients was superior to that of LDK recipients beyond the 10th year after transplantation (hazard ratio 0.55; P = 0.005). In summary, the early survival advantage of LDK over SPK is lost during long-term follow-up, probably as a result of improved glycemic control in SPK recipients.
引用
收藏
页码:1557 / 1563
页数:7
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