A roadmap to advance delirium research: Recommendations from the NIDUS Scientific Think Tank

被引：40

作者：

Oh, Esther S. ^{[1
]}

Akeju, Oluwaseun ^{[2
]}

Avidan, Michael S. ^{[3
]}

Cunningham, Colm ^{[4
,5
]}

Hayden, Kathleen M. ^{[6
]}

Jones, Richard N. ^{[7
]}

Khachaturian, Ara S. ^{[8
]}

Khan, Babar A. ^{[9
]}

Marcantonio, Edward R. ^{[10
]}

Needham, Dale M. ^{[11
]}

Neufeld, Karin J. ^{[12
]}

Rose, Louise ^{[13
]}

Spence, Jessica ^{[14
,15
]}

Tieges, Zoe ^{[16
]}

Vlisides, Phillip ^{[17
]}

Inouye, Sharon K. ^{[18
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[2] Harvard Med Sch, Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02115 USA

[3] Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA

[4] Trinity Coll Dublin, Sch Biochem & Immunol, Dublin, Ireland

[5] Trinity Coll Dublin, Trinity Coll Inst Neurosci, Dublin, Ireland

[6] Wake Forest Sch Med, Dept Social Sci & Hlth Policy, Div Publ Hlth Sci, Winston Salem, NC 27101 USA

[7] Brown Univ, Dept Psychiat & Human Behav, Warren Alpert Med Sch, Providence, RI 02912 USA

[8] Campaign Prevent Alzheimers Dis, Rockville, MD USA

[9] Indiana Univ Sch Med, Dept Med, Div Pulm Crit Care Sleep & Occupat Med, Indianapolis, IN 46202 USA

[10] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Gen Med, Boston, MA 02115 USA

[11] Johns Hopkins Univ, Sch Med, Div Pulm & Crit Care Med, Baltimore, MD USA

[12] Johns Hopkins Univ, Dept Psychiat & Behav Med, Sch Med, Baltimore, MD USA

[13] Kings Coll London, Florence Nightingale Fac Nursing Midwifery & Pall, London, England

[14] McMaster Univ, Dept Anesthesiol, Hamilton, ON, Canada

[15] McMaster Univ, Dept Crit Care, Hamilton, ON, Canada

[16] Univ Edinburgh, Edinburgh Delirium Res Grp, Edinburgh, Midlothian, Scotland

[17] Univ Michigan, Dept Anesthesiol, Med Sch, Ann Arbor, MI 48109 USA

[18] Harvard Med Sch, Marcus Inst Aging Res, Hebrew SeniorLife, Boston, MA 02115 USA

来源：

ALZHEIMERS & DEMENTIA | 2020年 / 16卷 / 05期

关键词：

biomarkers; definition; delirium; dementia; diagnosis; measurement; pathophysiology; prevention; public health campaign; treatment; EFFICIENT; PROGRESS; TRIAL; RISK; EEG;

D O I：

10.1002/alz.12076

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Delirium is an acute disorder of attention and cognition. It occurs across the life span, yet it is particularly common among older adults, and is closely linked with underlying neurocognitive disorders. Evidence is mounting that intervening on delirium may represent an important opportunity for delaying the onset or progression of dementia. To accelerate the current understanding of delirium, the Network for Investigation of Delirium: Unifying Scientists (NIDUS) held a conference "Advancing Delirium Research: A Scientific Think Tank" in June 2019. This White Paper encompasses the major knowledge and research gaps identified at the conference: advancing delirium definition and measurement, understanding delirium pathophysiology, and prevention and treatment of delirium. A roadmap of research priorities is proposed to advance the field in a systematic, interdisciplinary, and coordinated fashion. A call is made for an international consortium and biobank targeted to delirium, as well as a public health campaign to advance the field.

引用

页码：726 / 733

页数：8

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