The journey of the organelle: teamwork and regulation in intracellular transport

被引：49

作者：

Barlan, Kari ^{[1
]}

Rossow, Molly J. ^{[1
]}

Gelfand, Vladimir I. ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Cell & Mol Biol, Chicago, IL 60611 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2013年 / 25卷 / 04期

基金：

美国国家卫生研究院;

关键词：

OF-WAR MODELS; AXONAL-TRANSPORT; DYNEIN; MOTOR; BINDING; FORCE; LIS1; MICROTUBULES; MITOCHONDRIA; MECHANISM;

D O I：

10.1016/j.ceb.2013.02.018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Specific subsets of biochemical reactions in eukaryotic cells are restricted to individual membrane compartments, or organelles. Cells, therefore, face the monumental task of moving the products of those reactions between individual organelles. Because of the high density of the cytoplasm and the large size of membrane organelles, simple diffusion is grossly insufficient for this task. Proper trafficking between membrane organelles thus relies on cytoskeletal elements and the activity of motor proteins, that act both in transport of membrane compartments and as tethering agents to ensure their proper distribution and to facilitate organelle interactions.

引用

页码：483 / 488

页数：6

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