Neurons in the pontomedullary reticular formation signal posture and movement both as an integrated behavior and independently

被引:100
作者
Schepens, Benedicte [2 ]
Stapley, Paul [3 ]
Drew, Trevor [1 ]
机构
[1] Univ Montreal, Fac Med, Dept Physiol, GRSNC, Montreal, PQ H3C 3J7, Canada
[2] Univ Catholique Louvain, Dept Educ Phys & Readaptat, Unite Physiol & Biomecan Locomot, B-1348 Louvain, Belgium
[3] McGill Univ, Dept Kinesiol & Phys Educ, Balance & Voluntary Movement Lab, Montreal, PQ H3A 2T5, Canada
基金
加拿大健康研究院;
关键词
D O I
10.1152/jn.01381.2007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We have previously suggested that the discharge characteristics of some neurons in the pontomedullary reticular formation (PMRF) are contingent on the simultaneous requirement for activity in both ipsilateral flexor muscles and contralateral extensors. To test this hypothesis we trained cats to stand on four force platforms and to perform a task in which they were required to reach forward with one forelimb or the other and depress a lever. As such the task required the cat to make a flexion movement followed by an extension in the reaching limb while maintaining postural support by increasing extensor muscle tonus in the supporting limbs. We recorded the activity of 131 neurons from the PMRF of three cats during left, ipsilateral reach. Of these, 86/131 (66%) showed a change in discharge frequency prior to the onset of activity in one of the prime flexor muscles and 43/86 (50%) showed a bimodal pattern of discharge in which activity decreased during the lever press. Among the remaining cells, 28/86 (33%) showed maintained activity throughout the reach and the lever press. Most cells showed a broadly similar pattern of discharge during reaches with the right, contralateral limb. We suggest these results support the view that a population of neurons within the PMRF contributes to the control of movement in one forelimb and the control of posture in the other forelimb as a coordinated unit. Another population of neurons contributes to the control of postural support independently of the nature of the activity in the reaching limb.
引用
收藏
页码:2235 / 2253
页数:19
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