Synthesis of a radiolabelled Retinoid X Receptor (RXR) specific ligand

被引：0
|
作者：
Held, P
Heck, MP
Iyer, J
Gronemeyer, H
Lebeau, L
Mioskowski, C
机构：
[1] CEA SACLAY,SMM,DBCM,F-91191 GIF SUR YVETTE,FRANCE
[2] INST GENET & BIOL MOL & CELLULAIRE,F-67404 ILLKIRCH GRAFFENS,FRANCE
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1997年 / 39卷 / 06期
关键词：
retinoid; SR11237; tritium; synthesis;
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Synthesis of 4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen- 2-yl)-[1,3]dioxolan-2-yl]-benzoic acid or SR11237, a specific ligand of Retinoid X Receptors, is described in a H-3-labelled version. The labelled retinoid was prepared in 5 steps and tritium was introduced through a final reduction of an aromatic dihalide moiety with H-3(2).
引用
收藏
页码：501 / 507
页数：7
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