Synthesis of a radiolabelled Retinoid X Receptor (RXR) specific ligand

被引：0
|
作者：
Held, P
Heck, MP
Iyer, J
Gronemeyer, H
Lebeau, L
Mioskowski, C
机构：
[1] CEA SACLAY,SMM,DBCM,F-91191 GIF SUR YVETTE,FRANCE
[2] INST GENET & BIOL MOL & CELLULAIRE,F-67404 ILLKIRCH GRAFFENS,FRANCE
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1997年 / 39卷 / 06期
关键词：
retinoid; SR11237; tritium; synthesis;
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Synthesis of 4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen- 2-yl)-[1,3]dioxolan-2-yl]-benzoic acid or SR11237, a specific ligand of Retinoid X Receptors, is described in a H-3-labelled version. The labelled retinoid was prepared in 5 steps and tritium was introduced through a final reduction of an aromatic dihalide moiety with H-3(2).
引用
收藏
页码：501 / 507
页数：7
相关论文
共 50 条
  • [11] RXR - RETINOID RECEPTOR OR COFACTOR
    MANGELSDORF, DJ
    EVANS, RM
    HEYMAN, RA
    CALCIFIED TISSUE INTERNATIONAL, 1994, 54 (04) : 331 - 331
  • [12] Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA
    Xiaohua Lou
    Gudrun Toresson
    Cindy Benod
    Ji Ho Suh
    Kevin J Philips
    Paul Webb
    Jan-Ake Gustafsson
    Nature Structural & Molecular Biology, 2014, 21 : 277 - 281
  • [13] Structure of the retinoid X receptor α-liver X receptor β (RXRα-LXRβ) heterodimer on DNA
    Lou, Xiaohua
    Toresson, Gudrun
    Benod, Cindy
    Suh, Ji Ho
    Philips, Kevin J.
    Webb, Paul
    Gustafsson, Jan-Ake
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2014, 21 (03) : 277 - 281
  • [14] Ligand binding and heterodimerization with retinoid X receptor α (RXRα) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
    Wang, Na
    Zou, Qingan
    Xu, Jinxin
    Zhang, Jiancun
    Liu, Jinsong
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (47) : 18180 - 18191
  • [15] ISOFORM-SPECIFIC RETINOID-X RECEPTOR (RXR) ANTIBODIES DETECT DIFFERENTIAL EXPRESSION OF RXR PROTEINS IN THE PITUITARY-GLAND
    SUGAWARA, A
    YEN, PM
    QI, YP
    LECHAN, RM
    CHIN, WW
    ENDOCRINOLOGY, 1995, 136 (04) : 1766 - 1774
  • [16] DEVELOPMENTAL EXPRESSION OF MURINE RETINOID-X-RECEPTOR (RXR) GENES
    DOLLE, P
    FRAULOB, V
    KASTNER, P
    CHAMBON, P
    MECHANISMS OF DEVELOPMENT, 1994, 45 (02) : 91 - 104
  • [17] Influence of selective agonists of retinoid receptor X (RXR) and retinoid acid receptor (RAR) on bone metabolism in rats
    Beata Nowak
    Agnieszka Matuszewska
    Anna Merwid-Ląd
    Małgorzata Pieśniewska
    Lidia Fereniec-Gołębiewska
    Joanna Kwiatkowska
    Adam Szeląg
    Pharmacological Reports, 2013, 65 (Suppl 1) : 71 - 71
  • [18] Retinoid X receptor (RXR) β gene expression in papillary thyroid carcinoma
    Tang, W
    Nakamura, Y
    Zuo, H
    Yasuoka, H
    Nakamura, M
    Mori, I
    Miyauchi, A
    Kakudo, K
    MODERN PATHOLOGY, 2003, 16 (01) : 110A - 110A
  • [19] Up regulation of retinoid acid receptor x (RXRα) in uterine leiomyosarcomas
    Zhu, H
    Mittal, K
    Melamed, J
    Goswami, S
    Chiriboba, L
    Wei, JJ
    LABORATORY INVESTIGATION, 2005, 85 : 210A - 210A
  • [20] Retinoid X receptor (RXR) β gene expression in papillary thyroid carcinoma
    Tang, W
    Nakamura, Y
    Zuo, H
    Yasuoka, H
    Nakamura, M
    Mori, I
    Miyauchi, A
    Kakudo, K
    LABORATORY INVESTIGATION, 2003, 83 (01) : 110A - 110A
12345