Cancer associated fibroblast: Mediators of tumorigenesis

被引：36

作者：

Alexander, Jennifer ^{[1
,2
,3
]}

Cukierman, Edna ^{[1
,3
]}

机构：

[1] Fox Chase Canc Ctr, Canc Biol, 7701 Burholme Ave, Philadelphia, PA 19111 USA

[2] Fox Chase Canc Ctr, Mol Therapeut, 7701 Burholme Ave, Philadelphia, PA 19111 USA

[3] Fox Chase Canc Ctr, Marvin & Concetta Greenberg Pancreat Canc Inst, 7701 Burholme Ave, Philadelphia, PA 19111 USA

来源：

MATRIX BIOLOGY | 2020年 / 91-92卷

关键词：

MUSCLE ACTIN EXPRESSION; EXTRACELLULAR-MATRIX; BREAST-CANCER; DYNAMIC RECIPROCITY; TUMOR STROMA; TISSUE ARCHITECTURE; PALLADIN EXPRESSION; INVASIVE MOTILITY; BUNDLING PROTEINS; CELLS;

D O I：

10.1016/j.matbio.2020.05.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is well accepted that the tumor microenvironment plays a pivotal role in cancer onset, development, and pro-gression. The majority of clinical interventions are designed to target either cancer or stroma cells. These emphases have been directed by one of two prevailing theories in the field, the Somatic Mutation Theory and the Tissue Organization Field Theory, which represent two seemingly opposing concepts. This review proposes that the two theories are mutually inclusive and should be concurrently considered for cancer treatments. Spe-cifically, this review discusses the dynamic and reciprocal processes between stromal cells and extracellular matrices, using pancreatic cancer as an example, to demonstrate the inclusivity of the theories. Furthermore, this review highlights the functions of cancer associated fibroblasts, which represent the major stromal cell type, as important mediators of the known cancer hallmarks that the two theories attempt to explain. (c) 2020 Elsevier B.V. All rights reserved.

引用

页码：19 / 34

页数：16

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